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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE MALATE DEHYDROGENASE MDH
CommentsML1091, len: 329 aa. Probable mdh, Malate dehydrogenase (EC 1.1.1.37). Identical to the previously sequenced Mycobacterium leprae malate dehydrogenase SW:MDH_MYCLE (P50917) (329 aa), Fasta scores: E(): 0, 99.7% identity in 329 aa overlap. Also highly similar to many other malate dehydrogenases including: Mycobacterium tuberculosis Rv1240 SW:MDH_MYCTU (O54592) (329 aa), Fasta scores: E(): 0, 89.1% identity in 329 aa overlap and Thermus aquaticus SW:MDH_THEFL (P10584) (327 aa), Fasta scores: E(): 0, 63.7% identity in 325 aa overlap. Contains Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Contains PS00068 Malate dehydrogenase active site signature. BELONGS TO THE LDH FAMILY. MDH SUBFAMILY.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS12546741255663+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1091|mdh
VSPRPLKVAVTGAAGQIGYSLLFRLASGSLLGLDRPIELRLLEIEPALKALEGVVMELDDCAFLLLAGVEIGADPNKVFDGVNLALLVGARPRGPGMERGDLLEANGAIFTAQGKALNAVAAADIRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAIAQLATKTGSAVTDIRKMTIWGNHSATQYPDVFHAEIGGKNAAEVVGDQAWIEDYFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPEGNWVSMAVVSDGSYGVPEGLISSFPVTTTDGDWTIVRGLGIDDFSRGRIDKSTAELADERMAVKQLGLI
      
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