Gene ML1091
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE MALATE DEHYDROGENASE MDH |
| Comments | ML1091, len: 329 aa. Probable mdh, Malate dehydrogenase (EC 1.1.1.37). Identical to the previously sequenced Mycobacterium leprae malate dehydrogenase SW:MDH_MYCLE (P50917) (329 aa), Fasta scores: E(): 0, 99.7% identity in 329 aa overlap. Also highly similar to many other malate dehydrogenases including: Mycobacterium tuberculosis Rv1240 SW:MDH_MYCTU (O54592) (329 aa), Fasta scores: E(): 0, 89.1% identity in 329 aa overlap and Thermus aquaticus SW:MDH_THEFL (P10584) (327 aa), Fasta scores: E(): 0, 63.7% identity in 325 aa overlap. Contains Pfam match to entry PF00056 ldh, lactate/malate dehydrogenase. Contains PS00687 Aldehyde dehydrogenases glutamic acid active site. Contains PS00068 Malate dehydrogenase active site signature. BELONGS TO THE LDH FAMILY. MDH SUBFAMILY. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1254674 | 1255663 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1091|mdh
VSPRPLKVAVTGAAGQIGYSLLFRLASGSLLGLDRPIELRLLEIEPALKALEGVVMELDDCAFLLLAGVEIGADPNKVFDGVNLALLVGARPRGPGMERGDLLEANGAIFTAQGKALNAVAAADIRVGVTGNPANTNALIAMTNAPDIPRERFSALTRLDHNRAIAQLATKTGSAVTDIRKMTIWGNHSATQYPDVFHAEIGGKNAAEVVGDQAWIEDYFIPTVAKRGAAIIDARGASSAASAASATIDAARDWLLGTPEGNWVSMAVVSDGSYGVPEGLISSFPVTTTDGDWTIVRGLGIDDFSRGRIDKSTAELADERMAVKQLGLI
Bibliography
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