Gene ML1134
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE PEPTIDE CHAIN RELEASE FACTOR 1 PRFA (RF-1) |
| Comments | ML1134, len: 361 aa. Probable prfA, peptide chain release factor 1. Identical to the previously sequenced Mycobacterium leprae peptide chain release factor 1 (RF-1), directing the termination of translation, SW:RF1_MYCLE (P45833) (357 aa), Fasta scores: E(): 0, 99.7% identity in 357 aa overlap. Also highly similar to many other Prokaryotic and Eukaryotic chain release factors e.g. from Mycobacterium tuberculosis Rv1299 SW:RF1_MYCTU (Q10605) (357 aa), Fasta scores: E(): 0, 89.4% identity in 360 aa overlap and Kluyveromyces lactis (Yeast) SW:RF1M_KLULA (P41767) (396 aa), Fasta scores: E(): 0, 39.9% identity in 368 aa overlap. Contains Pfam match to entry PF00472 RF-1, Peptidyl-tRNA hydrolase domain. Also similar to M. leprae ML0667. Contains PS00745 Prokaryotic-type class I peptide chain release factors signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1325822 | 1326907 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1134|prfA
MAQPVQSIDVLLIEHAELELALADPELHSNPAEARKAGRRFARLAPIVATHRKLISARDDLQTARELAAGDESFADEIAELESRIAELTTQLTDMLAPHDPHGPDDIVLEVKSGEGGEESALFAADLARMYIRYAERHGWTVTVLDETTSDLGGYKDATLAISHKGASDGDAVDGVWSRMKFEGGVHRVQRVPVTESQGRVHTSAAGVLVYPEPEEIGEVHIDESDLRIDVYRSSGKGGQGVNTTDSAVRITHLPTGVVVTCQNERSQLQNKTRALQVLAARLQAMAEEQALANASADRASQIRTVDRSERIRTYNFPENRITDHRIGYKAHNLDQVLDGDLDALFDALSAADKQSRLQQV
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