Gene ML1151c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | REPAIR OF ALKYLATED GUANINE IN DNA BY STOICHIOMETRICALLY TRANSFERRING THE ALKYL GROUP AT THE O-6 POSITION TO A CYSTEINE RESIDUE IN THE ENZYME. THIS IS A SUICIDE REACTION: THE ENZYME IS IRREVERSIBLY INACTIVATED [CATALYTIC ACTIVITY : DNA (CONTAINING 6-O-METHYLGUANINE) + [PROTEIN]-L-CYSTEINE = DNA (WITHOUT 6-O-METHYLGUANINE) + PROTEIN S-METHYL-L-CYSTEINE.] |
| Product | PROBABLE METHYLATED-DNA--PROTEIN-CYSTEINE METHYLTRANSFERASE OGT (6-O-methylguanine-DNA methyltransferase) (O-6-methylguanine-DNA-alkyltransferase) |
| Comments | ML1151c, len: 165 aa. Probable methylated-DNA-protein-cysteine methyltransferase (EC 2.1.1.63). Identical to the previously sequenced Mycobacterium leprae putative methylated-DNA--protein-cysteine methyltransferase (EC 2.1.1.63) SW:OGT_MYCLE (P52982) (165 aa), Fasta scores: E(): 0, 100.0% identity in 165 aa overlap. Also highly similar to many others e.g. Mycobacterium tuberculosis Rv1316c SW:OGT_MYCTU (Q10627) (165 aa), Fasta scores: E(): 0, 78.2% identity in 165 aa overlap and Bacillus subtilis SW:OGT_BACSU (P11742) (165 aa), Fasta scores: E(): 1e-20, 44.7% identity in 159 aa overlap. Contains Pfam match to entry PF01035 Methyltransf_1, 6-O-methylguanine DNA methyltransferase. Contains PS00374 Methylated-DNA--protein-cysteine methyltransferase active site. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1346363 | 1346860 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1151c|ogt
MIHCRSMDSPIGPLILAGHGSVLTNLQMVDQTYEPSRVGWLPENGAFAEAVSQLDAYFAGELTEFAIELDLCGTEFQQRVWQALLTIPYGETRSYGEIAEQVGAPGAARAVGLANSRNPIAIIVPCHRVIGASGQLIGYGGGLNRKLTLLELEKHQVLTSLTLFD
Bibliography
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