Gene ML1174
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | RNase PH IS A PHOSPHOROLYTIC EXORIBONUCLEASE THAT REMOVES NUCLEOTIDE RESIDUES FOLLOWING THE -CCA TERMINUS OF tRNA AND ADDS NUCLEOTIDES TO THE ENDS OF RNA MOLECULES BY USING NUCLEOSIDE DIPHOSPHATES AS SUBSTRATES [CATALYTIC ACTIVITY: {TRNA}(N+1) + PHOSPHATE = {TRNA}(N) + A NUCLEOSIDE DIPHOSPHATE]. |
| Product | PROBABLE RIBONUCLEASE RPHA (RNase PH) (tRNA nucleotidyltransferase) |
| Comments | ML1174, len: 259 aa. Probable rphA ribonuclease (EC 2.7.7.56). Identical to the previously sequenced Mycobacterium leprae probable ribonuclease PH SW:RNPH_MYCLE (P37939) (259 aa), Fasta scores: E(): 0, 99.6% identity in 259 aa overlap. Also highly similar to many other ribonucleases including: Mycobacterium tuberculosis Rv1340 SW:RNPH_MYCTU (Q10628) (259 aa), Fasta scores: E(): 0, 88.8% identity in 259 aa overlap and Escherichia coli SW:RNPH_ECOLI (P03842) (238 aa), Fasta scores: E(): 0, 55.7% identity in 237 aa overlap. Contains Pfam match to entry PF01138 RNase_PH, 3' exoribonuclease family. Contains PS01277 Ribonuclease PH signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1370971 | 1371750 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1174|rphA
VSTRADGRLDDELRAVVITRGFTEHPAGSVLIEFGHTKVMCTASPTEGVPRWRKGSGKGWLTAEYAMLPSATHTRSERESVKGRLSGRTQEISRLIGRSLRACIDLAALGENTIAVDCDVLQADGGTRTAAVTGAYVALADAVTYLSAAGRLLDPRPLSCAIAAVSVGVVDGRIRVDLSYEEDSRAEVDMNVIATDTGTLVEIQGTGEGATFPRSTLDKLLDMALGACDKLFVAQRDALALPYQGMSPEGPPPPKAFGS
Bibliography
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