Gene ML1191
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) |
| Comments | ML1191, len: 3076 aa. Probable fas, fatty acid synthase (EC 2.3.1.-). Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa), Fasta scores: E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa), Fasta scores: E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa), Fasta scores: E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. Contains PS00606 Beta-ketoacyl synthases active site. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1396625 | 1405855 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1191|fas
VTIHEHDQVSADRNGNSLHGSRALADRLKAGEPYVVAFGGQGSAWLETLEELVSSAGLEADLATLVCEVELLLEPVAKELVVVRPIGFEPLQWVRALLAEDLVPSDKHLTSAAVSVPGVLLTQIAVGRALARQGMDLIATPPVGIVGHSQGVLAVEALKAGGARDAELLAMAQLIGAAGTLVARRRGISVLGDRPPMVSVTNADPERIRRLLDEFAQDVRTVLPPVLSIRNGWRSVVITGTPEQLSRFERYCRQISDKEEEDRRKKIRGGDIFAPVFDPVQVEIGFHTPHLADGIGIVGGWAEKVGLDVTLARELTEAILVRGVDWVREITRVHGAGVRWIIDLGPGDILTRLTAPVIRGLGVGIVPVANRGGQRTLFTVGAVPEVVRAWLSYAPTVVQLPDGRIKLSTKFTRLTGRSPILLAGMTPTTVDANIVAAAANAGHWAELAGGGQVTEEIFANRVEQLSGLLEPGRTYQFNALFLDPYLWKLQVGGKRLVQKARQSGAAIDGVVISGGILDLEDAVELIEELGGIGISYVVFKPGTIEQIRSVIRIATEMSTKPVIMHVEGGRAGGHHSWEDLDDLLLATYSELRSHANITVCVGGGIGTPEKAAEYLSGRWAQAYGFPLMPIDGILVGTAAMATKEATTSPSVKRMLVETQGTDQWIGSGKAQGGMASSRSQLGADIHEIDNAASRCGRLLDEVAGDAEAVAERRDEIIAAMANTAKPYFGDVSEMTYLQWLQRYVELTIGEGNSTADTASPGSPWLADTWRDRFQKMLQRAESRLHPSDFGLIKTIFTDPVLLEKPNQAIAALLKYYPDAETVQLHPADAPFFVMLCQMLGKPVNFVPVIDKDVRRWWRSDSLWQAHDARYDADQVCIIPGIAAVAGITQMDEPVGELLDRFEQAAIDEVLAGGAEPVVVMSRRLGRADVAGPLAVVLDAPDVLWAGRIATNPVHRIADPNEWQVNGNLSATHSSTGAQLQVKSEDQQVVLSVPVSNGWIDIPFTLPTNTVDGGALLVSTEDATSAMRAVLAIVAGVDGPELLSPVKDGTAIVTVDWNPERVADHTGVTATFREPLAPSLATVPDALVGACWPAVFSAIGSAVTEAGVLVVEGLLNLLHLDHAVCVVGKLPTVPAQLTVTATVSLAIDTDMGRVVPVSVTIRDTTGADGAVLATLEERFVILGRTGTAELTGPVRAGGAISENATDTPRRRRRDVTLTAPIDMRPFAVVSGDHNPIHTDRTAALLAGLESPIVHGMWLSAAAQHVVMATDGQARPAARLIGWTARFLGMAHPGDKVDFRVDRIGIDQGAEILEVSARISSGLVMSATARLAAPKTVYAFPGQGIQHKGMGMDVRARSKAARRVWDDADKFTRSGLGFSVLHVVRDNPTNITANGVHYHHPDGVLYLTQFTQVAMATVAVAQVAEMREQGAFVEGAIACGHSVGEYTALACVMGVYELEALLETVFHRGSKMHDIVLRDELGRSNYRLAAIRPSQIGLPDDEVPAFVRGIAESTGEFLEIVNFNLRGSQYAIAGTVHGLEALEAEVERRRELTGGRRSFILVPGIDVPFHSRVLRVGVAEFRRSLDRVLPQDQDPDWIIGRYIPNLVPRPFTLARDFIQEIRDLVPAEPLDDILADYDTWRRERPSEMARRVLIELLAWQFASPVRWIETQDLLFTEEAAGGLGVERFVEIGVKSAPTVAGLATDTLKLPEYSHNTVEVLNVERDAAVLFATDTDPELEPEPENVSDASAALPAESALALGTVAPAPVVPSGPRPEDISFGAADATLALIALSAKMRLDQIEEMDSIESITDGASSRRNQLLVDLGSELSLGAIDGVAEADLAGLRSQVTKLARTYKPYGPVLSELINDQLRSALGPSGKRPGVIAERVKKIWELGDGWVKHVTVEIALGTREGTSVRGGPLGNLNEGALADVDSVDKAVDAAVASVAARHGVVVALPSAGSGGSATVDVAALSEFTDQITGHDGVLASAARLVLGQLGLDGPVTAAPATTDTGLIDLVTAELSTDWPRLVAPVFDVKKAVVFDDRWASAREDLVRLWLNDEGEIEAQWSHLSERFEGAGHVVATQATWWQGKSLAAGRQIHASLYGRIAAGAQNPDRGLYSSEIAVVTGASKGSIAASVAARLLDGGATVIATTSKLDEERITFYRALYRDHARYGAALWVVAANMASYSDIDALVEWIGNEQTESLGPQSIHIKDAQTPTLLFPFAAPRVIGDLSEAGARSEIEMKVLLWAVQRLIVGLSKIGTERDVASRLHVVLPGSPNRGMFGGDGAYGEAKSALDAVVSRWHAESSWAARVSLAHALIGWTRGTGLMGHNDVIVSAVEEAGVTTYSTDEMAAMLLDLCNAESKVAAAGTPITVDLTGGLGEVDLDMAELAAKAREDHAAQAAEDEATEASEVAGTIAALPSPPRGYTPASPHWDDLDVDPADLVVIVGGAEIGPYGSSRTRFEMEVAGELSAAGVLELVWTTGLIRWEDDPQPGWYDTESGELVDESELVERYHDTVVQRCGIREFVDDGTIDPDHAYPLLVSVFLDKDFAFVVSSEADARAFVEFDPEHTVIRPVPDSSDWQVIRKAGTEIRVPRKMKLSRVVGGQIPTGFDPTVWGISPDMVSSIDRVAVWSIVATVDAFLSAGFTPAEVMRYVHPSLVANTMGTGMGGGTSIQRLYHSSLLGRNKPNDIFQEILPNIVAAHVVQSYIGSYGSMIHPVAACATAAVSVEEGVDKIRLGKAELVVAGGIDDLTLEGIIGFGDMAATADTAMMRGRGIHDSKFSRPNDRRRLGFVEAQGGGTILLARGDLALKMGLPVFAVVAFAQSFGDGVHTSIPAPGLGALGAGRGGKDSPLVQSLAKLGVSADDIAVISKHDTSTLANDPNETELHERLADAMGRSAGAPLFVVSQKSLTGHAKGGAAVFQMMGLCQMLRDGVIPPNRSLDCVDEELAGAAHFVWLRDTLRLGEKFPLKAGMLTSLGFGHVSGLVALVHPQAFIAALDPGQRDDYQRRANVRLLAGQRRLASAIAGGAPMYERPPDRRFDHHVPEKLQEAAMLLNPAARLGDGDAYIG
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