Gene ML1192
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | BIOSYNTHESIS OF FATTY ACIDS AND LIPIDS. TRANSFERS THE 4'-PHOSPHOPANTETHEINE MOIETY FROM COENZYME A TO A SER OF ACYL-CARRIER PROTEIN. CATALYZES THE FORMATION OF HOLO-ACP, WHICH MEDIATES THE TRANSFER OF ACYL FATTY-ACID INTERMEDIATES DURING THE BIOSYNTHESIS OF FATTY ACIDS AND LIPIDS [CATALYTIC ACTIVITY: CoA + APO-[ACYL-CARRIER PROTEIN] = ADENOSINE 3',5'-BISPHOSPHATE + HOLO-[ACYL-CARRIER PROTEIN] ]. |
| Product | HOLO-[ACYL-CARRIER PROTEIN] SYNTHASE ACPS (HOLO-ACP SYNTHASE) (CoA:APO-[ACP]PANTETHEINEPHOSPHOTRANSFERASE) (CoA:APO-[ACYL-CARRIER PROTEIN]PANTETHEINEPHOSPHOTRANSFERASE) |
| Comments | ML1192, len: 130 aa. Probable acpS, holo-[acyl-carrier protein] synthase (EC 2.7.8.7). Identical to the previously sequenced Mycobacterium leprae holo-[acyl-carrier protein] synthase (ACP) SW:ACPS_MYCLE (Q9X7E3) (130 aa), Fasta scores: E(): 0, 99.2% identity in 130 aa overlap. Also highly similar to ACPs from Mycobacterium tuberculosis Rv2523c SW:ACPS_MYCTU (O53228) (130 aa), Fasta scores: E(): 0, 86.7% identity in 128 aa overlap and Escherichia coli SW:ACPS_ECOLI (P24224) (125 aa), Fasta scores: E(): 0.00025, 35.1% identity in 131 aa overlap. Contains Pfam match to entry PF01648 ACPS, 4'-phosphopantetheinyl transferase superfamily. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1405884 | 1406276 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1192|acpS
VGIVGVGIDLVSIPDFAEQVSQPGTVFMTIFTPGERRDASVKSSSAVCHLAARWAVKEAVIKAWSGSRFAQRPMLPENIHRDIEVVNDMWGRPRVRLTGAIAKHLTDVTIHVSLTHEGDIAAAVVILEVL
Bibliography
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