Gene ML1199
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIS PROTEIN SPECIFICALLY CATALYZES THE REMOVAL OF SIGNAL PEPTIDES FROM PROLIPOPROTEINS [CATALYTIC ACTIVITY : CLEAVAGE OF N-TERMINAL LEADER SEQUENCES FROM MEMBRANE PROLIPOPROTEINS. HYDROLYSES XAA-XBB-XBB-|-CYS, IN WHICH XAA IS HYDROPHOBIC (PREFERABLY LEU), XBB IS OFTEN SER OR ALA, XCC IS OFTEN GLY OR ALA, AND THE CYS IS ALKYLATED ON SULFUR WITH A DIACYLGLYCERYL GROUP]. |
| Product | PROBABLE LIPOPROTEIN SIGNAL PEPTIDASE LSPA |
| Comments | ML1199, len: 201 aa. Probable lspA, lipoprotein signal peptidase (EC 3.4.23.36). Identical to the previously sequenced Mycobacterium leprae lipoprotein signal peptidase TR:Q9X7E7 (EMBL:AL049478) (201 aa), Fasta scores: E(): 0, 100.0% identity in 201 aa overlap. Also highly similar to lipoprotein signal peptidases from: Mycobacterium tuberculosis Rv1539 SW:LSPA_MYCTU (Q10764) (202 aa), Fasta scores: E(): 0, 80.6% identity in 201 aa overlap and Bacillus subtilis SW:LSPA_BACSU (Q45479) (154 aa), Fasta scores: E(): 1.2e-12, 36.8% identity in 163 aa overlap. Contains Pfam match to entry PF01252 Peptidase_A8, Signal peptidase (SPase) II. Contains PS00855 Signal peptidases II signature. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1417032 | 1417637 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1199|lspA
MMGRVPDGPTGLAALVPSVEEAQAMLPPRRLRLLLSIAAVVLTLDIVTKVLAVKFLLPGKSVSIIGDTVTWTLVRNSGAAFSMATGYTWVLTLIATGVVIGIFWMGRRLVSSWWALGLGMILGGAMGNLVDRFFRAPAPLRGHVVDFLSIGWWPVFNVADPSVVVGAILLVVLSIFGFDFDTVGRRKAEFDIAGQRKAEQR
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