Gene ML1200
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | possible pseudouridine synthase |
| Comments | ML1200, len: 308 aa. Possible pseudouridine synthase. Identical to the previously sequenced Mycobacterium leprae putative pseudouridine synthase TR:Q9X7E8 (EMBL:AL049478) (308 aa), Fasta scores: E(): 0, 99.7% identity in 308 aa overlap orthologues of which are known to be responsible for the synthesis pseudouridine from uracil within the 23s rRNA. Also highly similar to several others e.g. Mycobacterium tuberculosis Rv1540 SW:Y04P_MYCTU (Q10786) (308 aa), Fasta scores: E(): 0, 88.9% identity in 307 aa overlap and Escherichia coli SW:RLUD_ECOLI (P33643) (326 aa), Fasta scores: E(): 9.8e-23, 34.3% identity in 312 aa overlap. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01129 Rlu family of pseudouridine synthase signature. |
| Functional category | Information pathways, Conserved hypotheticals |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1417756 | 1418682 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1200|ML1200
VTDRSMPIPEGLAGMRVDAGLARLLGLSRTAVAALAEDGGVELDGVQAGKSDRLTSGAWLQVRLCEAPAPLENTPVDIEDMTILYSDDDIVAVDKPAAVAAHASVGWAGPTVLGGLAAAGYRITTSGVPERQGIVHRLDVGTSGVMLVAISERAYTVLKRAFKCRTVDKRYHALVQGHPDPSSGTIDAPIGRHRGHTWKFAVTKDGRHSITHYDTLEAFVAASLLDVHLETGRTHQIRAHFAELHRPCCGDLVYGADPKLAKRLGLERQWLHARSLSFAHPADGRRVEIVSSYPPDLQHALDVLRAES
Bibliography
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