Gene ML1241 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameechA12
Gene length885 bp
IdentifierML1241
Location 1476554 bp
Protein summary information
Molecular mass31459.1 Da
Isoelectric point7.81
Protein length295 amino acids
Structural information
PFAMPF00378
Orthologs
M. tuberculosis H37RvRv1472
M. lepromatosis Mx1-22AMLPM_1241
Cross-references
UniProtP53526
Gene OntologyFatty acid metabolic process, Enoyl-coa hydratase activity
Enzyme Classification4.2.1.17
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productpossible enoyl-CoA hydratase/isomerase EchA12 (ENOYL HYDRASE) (UNSATURATED ACYL-CoA HYDRATASE) (CROTONASE)
CommentsML1241, len: 294 aa. Possible enoyl-CoA hydratase (EC 4.2.1.17). Highly similar to ECHC_MYCTU|O53163|Rv1472 EchA12 probable enoyl-CoA hydratase from Mycobacterium tuberculosis (285 aa), Fasta scores: E(): 0, (72.0% identity in 271 aa overlap) and CRT_CLOAB|P52046 acetobutylicum 3-hydroxybutyryl-CoA dehydratase from Clostridium (EC 4.2.1.55) (261 aa), Fasta scores: E(): 5.1e-18, (31.1% identity in 264 aa overlap). Also similar to ML1817c a possible pseudogene similar to M. tuberculosis echA12. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family. Contains PS00166 Enoyl-CoA hydratase/isomerase signature.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS14765541477438+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1241|echA12
VSQTDASCTIAELPYRSVTDLVVLDFPRPEVALITLNRPGRMNSMALDLMKSLKQVLKRITYDHSVRVVVLTGAGRGFCSGADQKFTAPVPQVEGLTQPVRALRAMELLEEVILALRRLHQPVIAAINGPAIGGGLCLALAADVRVASTRAYFRAAGINNGLSASELGLSYLLPRAVGSSRAFEIMLSGRDVGAEEAEQIGLVSYRVSDDRLLDTCYSIAARMATFSRSGTELTKRALWGGLDAASLDKHMQSESLAQLFIALHTSNFEEAAAPCTEKRPTVLVDARGCATSPG
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