Gene ML1331
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT. |
| Product | PROBABLE SEC-INDEPENDENT PROTEIN TRANSLOCASE MEMBRANE-BOUND PROTEIN TATA |
| Comments | ML1331, len: 95 aa. Probable tatA, membrane-bound protein, component of twin-arginine translocation protein export system (see Berks et al., 2000). Highly similar to others e.g. Streptomyces coelicolor putative secreted protein TR:Q9RJ68 (EMBL:AL132648) (95 aa), Fasta scores: E(): 5.1e-09, 45.3% identity in 86 aa overlap and Mycobacterium tuberculosis Rv2094c SW:YK94_MYCTU (Q10703) (83 aa), Fasta scores: E(): 5.2e-21, 68.2% identity in 88 aa overlap. Contains a possible N-terminal signal sequence. Note codon 8 may offer an alternative translational start site. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE TATA/E FAMILY. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1583188 | 1583475 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1331|tatA
MSGGKFKVGSLSPWHWVVLVVVVVLLFGAKKLPDAARSLGKSMRIFKSELREMQTENQAQASALETPMQNPTVVQSQRVVPPWSTEQDHTEARPA
Bibliography
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