Gene ML1332
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN PROTEINS EXPORT: REQUIRED FOR CORRECT LOCALIZATION OF PRECURSOR PROTEINS BEARING SIGNAL PEPTIDES WITH THE TWIN ARGININE CONSERVED MOTIF S/T-R-R-X-F-L-K. THIS SEC-INDEPENDENT PATHWAY IS TERMED TAT FOR TWIN-ARGININE TRANSLOCATION SYSTEM. THIS SYSTEM MAINLY TRANSPORTS PROTEINS WITH BOUND COFACTORS THAT REQUIRE FOLDING PRIOR TO EXPORT. |
| Product | Probable Sec-independent protein translocase transmembrane protein TatC |
| Comments | ML1332, len: 286 aa. Probable tatC, Sec-independent protein translocase transmembrane protein. Similar to many membrane proteins including: Escherichia coli Sec-independent protein translocase protein TatC SW:TATC_ECOLI (AJ005830) (258 aa), Fasta scores: E(): 1.6e-17, 33.0% identity in 267 aa overlap and Mycobacterium tuberculosis Rv2093c SW:YK93_MYCTU (Q10702) (308 aa), Fasta scores: E(): 0, 86.0% identity in 286 aa overlap. Contains multiple possible membrane spanning hydrophobic domains and a possible N-terminal signal sequence. Contains Pfam match to entry PF00902 UPF0032, MttB family. Contains PS01218 Uncharacterized protein family UPF0032 signature. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1583614 | 1584474 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1332|tatC
MSLIDHLTELRTRLLISLAAIVVTTIFGFIWYSHSIFGLESLGEWLRRPYCSLPQSARADISPDGQCRLLATAPFDQFMLRIKVGMAAGIVLASPVWFYQLWAFITPGLYTKERRFTVAFVVPAAVLFAGGTVLAYLVLSKALGFLLIVGSGVQVTALSGDRYFGFLLNLLVVFGVSFEFPLLIVMLNIAGLLTYQRLKSWRRGLIFAMFVFAAVFTPGSDPFSMTALGAALTVLLELAIQLVRLHDKRRVKHEALIADDEASVIEPPSSIPERSYTATRSHDDVT
Bibliography
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