Gene ML1340c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN RIBOFLAVIN BIOSYNTHESIS (AT THE SECOND AND THIRD STEPS). CONVERTS 2,5-DIAMINO-6-(RIBOSYLAMINO)-4(3H)-PYRIMIDINONE 5'-PHOSPHATE INTO 5-AMINO-6-(RIBOSYLAMINO)-2,4(1H,3H)-PYRIMIDINEDIONE 5'-PHOSPHATE [CATALYTIC ACTIVITY 1: 2,5-DIAMINO-6-HYDROXY-4-(5-PHOSPHORIBOSYLAMINO)PYRIMIDINE + H(2)O = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NH(3)] [CATALYTIC ACTIVITY 2: 5-AMINO-6-(5-PHOSPHORIBITYLAMINO)URACIL + NADP(+) = 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL + NADPH]. |
| Product | POSSIBLE BIFUNCTIONAL ENZYME RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBD: DIAMINOHYDROXYPHOSPHORIBOSYLAMINOPYRIMIDINE DEAMINASE (RIBOFLAVIN-SPECIFIC DEAMINASE) + 5-AMINO-6-(5-PHOSPHORIBOSYLAMINO)URACIL REDUCTASE (HTP REDUCTASE) |
| Comments | ML1340c, len: 268 aa. Possible ribD (alternate gene name: ribG), bifunctional riboflavin biosynthesis protein including diaminohydroxyphosphoribosylaminopyrimidine deaminase and 5-amino-6-(5-phosphoribosylamino) uracil reductase (EC 3.5.4.26 and 1.1.1.193). Similar to Mycobacterium tuberculosis Rv2671 TR:P71968 (EMBL:Z80225) bifunctional riboflavin biosynthesis protein (258 aa), Fasta scores: E(): 0, 72.9% identity in 251 aa overlap. And similar to the C-terminal reductase domains of several riboflavin biosynthetic proteins e.g. Escherichia coli RibD SW:RIBD_ECOLI (X64395) (367 aa), Fasta scores: E(): 0.0028, 23.8% identity in 227 aa overlap. Contains Pfam match to entry PF01872 RibD_C, RibD C-terminal domain. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1598386 | 1599192 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1340c|ribD
MSDFETGPAASTTAGRAAQTPLLMLTSGRYLDDDELSQLYGYPSERAGVWIRANFITSIDGGATADGRTGAMAGPGDRFVFNMLRELADVIVVGAGTVRIENYSGAHLPVTKRQQRQARGQSEVPQLAIVTNSGRLDRDMAVFTRTEIAPLVLTCTETAKKLRTRLADLAYVVSCSGDDPSKVDETVVLATLQTRGLRRVLTEGGPMLLGSFIQHGMLDELCLTIAPLIVGGRARRIATGPEQLLTRMRCAHVLTDDAGYLYTRYVKA
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