Gene ML1346 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1346
Gene length3009 bp
IdentifierML1346
Location 1606117 bp
Protein summary information
Molecular mass107755.0 Da
Isoelectric point6.8
Protein length1003 amino acids
Structural information
PFAMPF00501, PF00561
Orthologs
M. tuberculosis H37RvRv1683
M. lepromatosis Mx1-22AMLPM_1346
Cross-references
UniProtQ9CC34
Gene OntologyMetabolic process, Catalytic activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productpossible long-chain acyl-CoA synthase
CommentsML1346, len: 1002 aa. Possible long-chain acyl-CoA synthase. Similar to many Prokaryotic and Eukaryotic long-chain acyl-CoA synthetases including: Mus musculus SW:VLCS_MOUSE (O35488) (620 aa), Fasta scores: E(): 1.5e-20, 24.7% identity in 570 aa overlap and Chromatium vinosum poly-beta-hydroxybutyrate polymerase (EC 2.3.1.-) SW:PHBC_CHRvI (P45370) (355 aa), Fasta scores: E(): 4.7e-17, 28.2% identity in 348 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv1683 TR:O33185 (EMBL:Z98268) (999 aa), Fasta scores: E(): 0, 85.6% identity in 1002 aa overlap. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme. Contains PS00120 Lipases.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16061171609125+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1346|ML1346
VDLNFSIVTRPVERLVATAQNGLEVLRLGGLETGSFPSPSQIVESVPMYKLRRYFPPGNRPGQPLLGAPVLMVHPMMMSADMWDVTREEGAVGILHVRGLDPWVIDFGSPDKVEGGMRRNLADHIVALSEAVDTVKEVTGNDVHLVGYSQGGMFCYQAAAYRRSENIASIVAFGSPVDTLAALPMGIPPNFGVVLANFMADHVFNRLDIPSWLARAGFQMLDPLKTVKARVDFVRQLHNREALLSREQQRRFLESEGWIAWSGPAISELLKQFIAHNRMMTGGFAVNGQMVTLTDITCPVLAFVGEVDDIGQPASVRGIRRAAPNAEVYESLIRTGHFGLVVGSRAAQQSWPTVAEWVCWLAANANKPANIHIMPDQPVEHTASGVAISSRLAHGLGEVSETALALARGVADAIVAANRSVHTLAVETVRTLPRLARLGQLNDHTRISLGRIIGEQAHDAPRGEFLLFDGRVHTYEAVDRRVNNVVRGLIAVGVRQGDRVGVLMETRPSALVAIAALSRLGAVAVMMRPDADLAASVRIGGATKILTDPANLGVVLAYGRQLTGQVLVLGGGESRDLHLPEDALQQNQVIDMEKIDPNAVDLPAWYRPNSGLARDLAFIACSTVGGELVAKQITNYRWAVSAFGTASTAALDRRDTVYCLTPLHHESALLVSLGGAVVGGARIALSRGLCSNRFVHEVRQYGVTVVSYTWAMLRELVDDPAFVLHGNHPVRLFMGSGMPTGLWERVVEAFAPAHVVEFFATVDGQAVLANVSGAKIGSKGRPLPGAGHVELGAYDAEQDLILENDRGFVQVADVNQIGVLLAASRGPIDPTASVKRGVFAPADTWIATEYLLRRDYDGDYWLAGRRSSVVRTARGLVYTEPVTDALGFITGVDLAATYSVAVDDRELAVSAVTLLPGAAITAADLTEAVASMPVGLGPDIVHVVPELTLSATYRPIVGALRTAGIPKTGRQVWYFDSASNQFRRMTPGVRAELAGKHTHTHA
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