Gene ML1351 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namempg
Gene length645 bp
IdentifierML1351
Location 1611524 bp
Protein summary information
Molecular mass22295.2 Da
Isoelectric point8.29
Protein length215 amino acids
Structural information
PFAMPF02245
Orthologs
M. tuberculosis H37RvRv1688
M. lepromatosis Mx1-22AMLPM_1351
Cross-references
UniProtO05678
Gene OntologyAlkylbase dna n-glycosylase activity, Base-excision repair, Dna binding
Enzyme Classification3.2.2.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE 3-METHYLADENINE DNA GLYCOSYLASE MPG
CommentsML1351, len: 214 aa. Possible mpg, 3-methylpurine DNA glycosylase (EC 3.2.2.-). Similar to several DNA-3-methyladenine glycosylases from both Prokaryotes and Eukaryotes e.g. Bacillus subtilis SW:3MGH_BACSU (P94378) (196 aa), Fasta scores: E(): 7.7e-13, 38.4% identity in 185 aa overlap and Arabidopsis thaliana SW:3MG_ARATH (Q39147) (254 aa), Fasta scores: E(): 1.1e-11, 32.0% identity in 194 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1688 putative 3-methyladenine DNA glycosylase SW:3MGH_MYCTU (O33190) (203 aa), Fasta scores: E(): 0, 78.3% identity in 203 aa overlap. Note codon 12 may offer an alternative translational start site.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16115241612168+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1351|mpg
LRSPRRCKICAVSADQLVVDPVVAAHRLLGATITGRGVCAIVVEVEAYGGVPDGPWPDAAAHSYHGRNDRNAVMFGPPGRLYTYCSHGIHVCANVSCGPDGTAAAVLIRAGALENGADVARSRRGASVRTVALARGPGNLCSALGITMDDNGIDVFAADSPVTLVLNEAQEAMSGPRVGISHAADRPWRLWLPGRPEVSTYRRSPRAPAPGASD
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