Gene ML1358 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametlyA
Gene length810 bp
IdentifierML1358
Location 1618113 bp
Protein summary information
Molecular mass28171.3 Da
Isoelectric point5.87
Protein length270 amino acids
Structural information
PFAMPF01479, PF01728
Orthologs
M. tuberculosis H37RvRv1694
M. lepromatosis Mx1-22AMLPM_1358
Cross-references
UniProtO05676
Gene OntologyHemolysis by symbiont of host erythrocytes, Rna binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productcytotoxin/hemolysin homologue TlyA
CommentsML1358, len: 269 aa. Probable tlyA, cytotoxin/haemolysin homologue. Highly similar to several proposed hemolysins including: Mycobacterium ulcerans TlyA TR:CAB83047 (EMBL:AJ271681) (281 aa), Fasta scores: E(): 0, 81.0% identity in 268 aa overlap, Treponema hyodysenteriae hemolysin A SW:HLYA_TREHY (Q06803) (240 aa), Fasta scores: E(): 2.3e-23, 34.9% identity in 238 aa overlap and Mycobacterium tuberculosis Rv1694 TR:Q50760 (EMBL:X98295) (268 aa), Fasta scores: E(): 0, 78.4% identity in 268 aa overlap. Contains possible membrane spanning hydrophobic domains.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16181131618922+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1358|tlyA
VARRVRVDVELVRRGLARSRQQAAKLISAGKVSIDGLPAVKPSTAVAITTVLTVADDGERSWVSRGAHKLMGALDTFGIPVAGRCCLDAGASTGGFTEVLLDRGAAEVVAVDVGYGQLAWSVRCDPRVIVVERTNVHDLSPELIGGPVDLVVADLSFISLATVLSALAGCALPSADIVPMVKPQFEVGKGQVGPGGVVRDLRLRADSVLAVARRATELGWRTMDVTASSLPGLSGNVEYFLWLRAQTDLELSTDGLEAAVQRAIAEGPQ
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