Gene ML1363
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | Unknown |
| Product | Probable CTP synthase PyrG |
| Comments | ML1363, len: 590 aa. Probable pyrG, CTP synthase (EC 6.3.4.2). Highly similar to many CTP synthases, catalysing the last step in pyrimidine biosynthesis, including: Escherichia coli SW:PYRG_ECOLI (P08398) (544 aa), Fasta scores: E(): 0, 50.5% identity in 548 aa overlap and Mycobacterium tuberculosis Rv1699 SW:PYRG_MYCTU (P96351) (586 aa), Fasta scores: E(): 0, 89.2% identity in 590 aa overlap. Contains Pfam match to entry PF00117 GATase, Glutamine amidotransferase class-I. Contains PS00442 Glutamine amidotransferases class-I active site. |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1624156 | 1625928 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1363|pyrG
VRKHPQSATKHLFVSGGVASSLGKGLTASSLGQLLTARGLHVTMQKLDPYLNVDPGTMNPFQHGEVFVTEDGAETDLDVGHYERFLDRDLSGSANVTTGQVYSTVIAKERRGEYLGDTVQVIPHITDEIKQRIMAMAQPDGGDNRPDVVITEIGGTVGDIESQPFLEAARQVRHDLGRENVFFLHVSLVPHLAPSGELKTKPTQHSVAALRSIGITPDALILRCDRDVPESLKNKIALMCDVDIDGVISTPDAPSIYDIPKVLHREELDAFVVRRLNLPFRDVDWTEWDDLLRRVHEPHGTVRIALVGKYVDFSDAYLSVSEALHAGGFKHYAKVEVVWVASDDCETATGAAAVLADVHGVLIPGGFGIRGIEGKIGAIRYARARGLPVLGLCLGLQCIVIEATRSVGLVQANSAEFEPATPDPVISTMADQKEIVAGEADFGGTMRLGAYPAVLQPASIVAQAYGTTQVSERHRHRYEVNNAYRDWIAESGLRISGTSPDGYLVEFVEYPANMHPFVVGTQAHPELKSRPTRPHPLFVAFVGAAIDYKSAELLPVEIPAVPEISEHLPNSSNQHRDGVERSFPAPAARG
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