Gene ML1365 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1365
Gene length951 bp
IdentifierML1365
Location 1626542 bp
Protein summary information
Molecular mass33942.7 Da
Isoelectric point10.0
Protein length317 amino acids
Structural information
PFAMPF00589, PF02899
Orthologs
M. tuberculosis H37RvRv1701
M. lepromatosis Mx1-22AMLPM_1365
Cross-references
UniProtQ49890
Gene OntologyDna integration, Cell cycle, Cell division, Chromosome segregation, Cytoplasm, Transposition, dna-mediated, Tyrosine-based site-specific recombinase activity, Dna binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE INTEGRASE/RECOMBINASE
CommentsML1365, len: 316 aa. Probable integrase/recombinase. Highly similar to several including: Escherichia coli integrase/recombinase XerD which is involved in site specific recombination, SW:XERD_ECOLI (P21891) (298 aa), Fasta scores: E(): 5.7e-29, 40.3% identity in 308 aa overlap. Also similar to several other Mycobacterium tuberculosis integrase/recombinases e.g. Rv1701 TR:O33200 (EMBL:Z98268) (311 aa), Fasta scores: E(): 0, 85.9% identity in 311 aa overlap and Rv2894c SW:YS94_MYCTU (Q10815) (298 aa), Fasta scores: E(): 0, 42.9% identity in 312 aa overlap. Also similar to ML1365 from M. leprae. Contains Pfam match to entry PF00589 Phage_integrase, 'Phage' integrase family.
Functional categoryInsertion seqs and phages
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16265421627492+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1365|ML1365
VTTAALQTQLQGYLDYLIIERSIAANTLSSYRRDLIRYSKHLSDRGIEDLAKVGEHDVSEFLVALRRGDPDSGVAALSAVSAARALIAVRGLHRFAVAEGLVDLDVARAVRPPTPGRRLPKSLTVDEVLALLESVGGESRADGPLVLRNRALLELLYSTGSRISEAVGLDVDDVDTQARTVLLQGKGGKQRLVPVGRPAVQALDAYLVRGRSDLARRGPGMLATPAIFLNARGGRLSRQSAWQVLQDAAEHAGITSGVSPHMLRHSFATHLLEGGADIRVVQELMGHASVTTTQIYTLVTVQALREVWAGAHPRAK
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