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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductHypothetical pseudouridine synthase (Uracil hydrolyase)
CommentsML1370, len: 257 aa. Hypothetical pseudouridine synthase (EC 4.2.1.70). Highly similar to several pseudouridylate synthases involved in the modification of ribosomal RNA e.g. Bacillus subtilis ribosomal large subunit pseudouridine synthase B SW:RLUB_BACSU (P35159) (229 aa), Fasta scores: E(): 3.6e-30, 42.8% identity in 229 aa overlap. Also highly similar to Mycobacterium tuberculosis Rv1711 SW:YH11_MYCTU (O33210) (254 aa), Fasta scores: E(): 0, 80.2% identity in 257 aa overlap. Contains Pfam match to entry PF01479 S4, S4 domain. Contains Pfam match to entry PF00849 PseudoU_synth_2, RNA pseudouridylate synthase. Contains PS01149 Rsu family of pseudouridine synthase signature. Belongs to the pseudouridine synthase rsuA family.
Functional categoryInformation pathways, Conserved hypotheticals
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16304391631212+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1370|ML1370
LMVEIHDSRMDRGAGAVRLQKILSRAGIASRRAAEKLIIEGRVEVDGQLVRELGTRVDPDVSVVRVDGVKVVVDDSLVYLALNKPRGMYSTMSDDRGRPCVGDLIERRVRGNKKLFHVGRLDADTEGLILLTNDGELAHRLMHPSHEVSKTYLATVKGAVPRGLGKKLSVGLELDDGPAHVDDFAVVDAIPGKTLVRLTLHEGRKRIVRRLLTAAGFPVEMLVRTDIGAVSLGDQRPGCLRALLRDEIRQLYKEVGL
      
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