Gene ML1397 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametsnR
Gene length780 bp
IdentifierML1397
Location 1677111 bp
Protein summary information
Molecular mass27027.2 Da
Isoelectric point8.33
Protein length260 amino acids
Structural information
PFAMPF00588, PF08032
Orthologs
M. tuberculosis H37RvRv1644
M. lepromatosis Mx1-22AMLPM_1397
Cross-references
UniProtQ9CC19
Gene OntologyRna methyltransferase activity, Rna processing, Rna binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPossible 23S rRNA methyltransferase TsnR
CommentsML1397, len: 259 aa. Possible tsnR, 23S rRNA methyltransferase (EC 2.1.1.-). Similar to several proposed rRNA methylases (SpoU family) e.g. Mycobacterium tuberculosis Rv1644 TR:P94978 (EMBL:Z85982) (260 aa), Fasta scores: E(): 0, 72.8% identity in 257 aa overlap and Escherichia coli SW:TRMH_ECOLI (P19396) (1436 aa), BlastP Expect 7.5. Contains Pfam match to entry PF00588 SpoU_methylase, SpoU rRNA Methylase family.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS16771111677890+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1397|tsnR
VLTERSARVVAAVKLHRQVARRRVRRFLAEGPNLVEAAIVSGLVRDVFVTEVAAQRHATVLATLKCPVHPVSERAAKALSDTVTPTGLIAVCEMPTTRLATVLAGSPQLVVAAVEISEPGNAGTVIRIADAMGAAAVIFGGYTVDPYNGKCLRSSAGSIFSITVVVASDAYAAVTELRAAGLQVLATMVDGETSLDEAKPLLGKPTAWLFGSEPHGLSTEIAEAADYRVRIPMVGGVESLNVAATAAICLYQSSRALRL
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