Gene ML1448 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namesigC
Gene length555 bp
IdentifierML1448
Location 1740908 bp
Protein summary information
Molecular mass20118.7 Da
Isoelectric point7.06
Protein length185 amino acids
Structural information
PFAMPF04542, PF08281
Orthologues
M. tuberculosisRv2069
Cross-references
UniProtQ9CC01
Gene OntologySigma factor activity, Sequence-specific dna binding transcription factor activity, Dna-dependent transcription, initiation, Regulation of transcription, dna-dependent
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE RNA POLYMERASE SIGMA FACTOR, ECF SUBFAMILY, SIGC
CommentsML1448, len: 184 aa. Probable sigC, RNA polymerase sigma factor, ECF subfamily. Similar to many ECF-subfamily RNA polymerase sigma factors including: Bacillus subtilis SigX SW:SIGX_BACSU (P35165) (194 aa), Fasta scores: E(): 1.3e-07, 32.0% identity in 128 aa overlap and Mycobacterium tuberculosis Rv2069 SW:RPSC_MYCTU (Q10679) (185 aa), Fasta scores: E(): 0, 81.2% identity in 181 aa overlap. Also similar to ML1956c a possible pseudogene similar to M. tuberculosis sigC. Contains a putative helix-turn-helix motif situated between residues 156..177 (+2.77 SD). Contains a probable helix-turn-helix motif at aa 146-167 (Score 1052, SD +2.77) Contains Pfam match to entry PF00776 Sigma70_ECF, Sigma-70 factor (ECF subfamily). Contains PS01063 Sigma-70 factors ECF subfamily signature. Belongs to ECF subfamily.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS17409081741462+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1448|sigC
MIASSGDEAVTDLALAAARGSKRALEAFIKATQQDVWRFVAYLSDVGNADDLTQETFLRAIGAIERFSGHSSGRTWLLAIARRVVADHIRRAQTRPRTTFDGYPERMLNADRHARGFEDLVEVTTMIANLATEQREALLLTQLLGLPYADAAAVCGCPVGTIRSRVARARDALLADTEHNHLTG
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