Gene ML1478
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CATALYZES METHYL TRANSFER FROM S-METHYLMETHIONINE OR S-ADENOSYLMETHIONINE (LESS EFFICIENT) TO HOMOCYSTEINE, SELENOHOMOCYSTEINE AND LESS EFFICIENTLY SELENOCYSTEINE [CATALYTIC ACTIVITY: S-ADENOSYL-L-METHIONINE + L-HOMOCYSTEINE = S-ADENOSYL-L-HOMOCYSTEINE + L-METHIONINE]. |
| Product | PROBABLE HOMOCYSTEINE S-METHYLTRANSFERASE MMUM (S-METHYLMETHIONINE:HOMOCYSTEINE METHYLTRANSFERASE) (CYSTEINE METHYLTRANSFERASE) |
| Comments | ML1478, len: 293 aa. Probable mmuM, homocysteine S-methyltransferase (EC 2.1.1.10). Highly similar to many e.g. Escherichia coli homocysteine S-methyltransferase involved in methionine biosynthesis SW:MMUM_ECOLI (Q47690) (310 aa), Fasta scores: E(): 0, 49.8% identity in 293 aa overlap and Mycobacterium tuberculosis putative transferase Rv2458 TR:O53185 (302 aa), fasta score: E(): 7e-92, (78.840% identity in 293 aa overlap). |
| Functional category | Intermediary metabolism and respiration |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 1781330 | 1782211 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1478|mmuM
VGLAVHSESVLINDGGLATELEARGNDLSDPLWSARLLTDAPQEIVAVHVAYFRAGATIATTVSYQASFEGFAARGIGRDQAIRLMRRSVALASAARDEISAGGLCVAASVGPYGAALADGSEYRGRYGLSVAALARWHRPRLEVLADAGADVLALETIPDIDEAEALVDLVRSVGVPAWLSYTINGTRTRAGQPLAEAFAVAAGVPKIVAVGVNCCAPDDVLAAIQIANIGKPIIVYPNSGERWDYRTWTGPRRFSAQLALQWTAAGARIVGGCCRVRPADIAELTKALASR
Bibliography
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