Gene ML1514c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethyX
Gene length765 bp
IdentifierML1514c
Location 1825649 bp
Protein summary information
Molecular mass27934.8 Da
Isoelectric point7.02
Protein length255 amino acids
Structural information
PFAMPF02511
Orthologs
M. tuberculosis H37RvRv2754c
M. lepromatosis Mx1-22AMLPM_1514
Cross-references
UniProtQ9CBW3
Gene OntologyDtmp biosynthetic process, Thymidylate synthase (fad) activity, Flavin adenine dinucleotide binding
Enzyme Classification2.1.1.148
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE THYMIDYLATE SYNTHASE THYX (TS) (TSase)
CommentsML1514c, len: 254 aa. Probable thyX, Thymidylate synthase (EC 2.1.1.148). Highly similar to several e.g Mycobacterium tuberculosis thyX, Thymidylate synthase Rv2754c or MTV002.19C TR:O33296 (EMBL:AL008967) (250 aa) fasta scores: E(): 0, 81.5% identity in 254 aa and to Brevibacterium lactofermentum thyX, Thymidylate synthase SW:YDAP_BRELA (P40111) (250 aa) fasta scores: E(): 0, 59.4% identity in 249 aa. Also similar to mycobacteriophage proteins; Mycobacteriophage D29 protein 48 SW:VG48_BPMD2 (O64238) (235 aa) fasta scores: E(): 4.9e-30, 43.8% id in 249 aa
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18256491826413-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1514c|thyX
VAQIAPLRVQLIAKTEFLAPPDVSWTTDADGGSALVEFAGRACYQSWSKPNPRTATNAAYIKHIIDVGHVAVLEHASVSFYISGISRSCTHELIRHRHFSYSQLSQRYVPEKDAQVVVPPDMEDDDELQQILIAAVEASRATYTELLVKLNAKLMAGELGGNRAVLRRKQARQAAHAVLPNANETRIVVTGNYRAWRHFIAMRASEHADVEIRRLAIVCLRRLVDVAPAVFADFEITALADGTEVATSPLATEA
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