Gene ML1518c (folA) in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namedfrA
Gene length498 bp
IdentifierML1518c
Location 1832480 bp
Protein summary information
Molecular mass18509.1 Da
Isoelectric point4.81
Protein length166 amino acids
Structural information
PFAMPF00186
Orthologs
M. tuberculosis H37RvRv2763c
M. lepromatosis Mx1-22AMLPM_1518
Cross-references
UniProtQ9CBW1
Gene OntologyDihydrofolate reductase activity, Glycine biosynthetic process, Nucleotide biosynthetic process, One-carbon metabolic process, Oxidation-reduction process, Nadp binding
Enzyme Classification1.5.1.3
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductDIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)
CommentsML1518c, len: 165 aa. Probable dfrA, dihydrofolate reductase (EC 1.5.1.3). Highly similar to many dihydrofolate reductases including: Escherichia coli SW:DYR_ECOLI (P00379) (159 aa), Fasta scores: E(): 2e-15, 38.4% identity in 146 aa overlap and several reductases from Mycobacteria including M. tuberculosis Rv2763c TR:O30463 (EMBL:AF006616) (181 aa), Fasta scores: E(): 0, 68.9% identity in 161 aa overlap and M. avium TR:O30463. Contains Pfam match to entry PF00186 DiHfolate_red, Dihydrofolate reductase. Contains PS00075 Dihydrofolate reductase signature. Note previously known as folA.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18324801832977-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1518c|dfrA
MTVVGLIWAQSTTGVIGRDGGMPWRVPEDLTRFKQLTMGHPVVMGRRTWDSLPVGVRPLPGRRNIVLSRQIDFMAEGAEVFGSLEETISNLETEPEMWVIGGEQIYRLALPLATRCGVTEVDTYLLHEDDDVLAPVLDDTWVGVTGEWLVSCSGLRYRLHSYHRS
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