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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE)
CommentsML1519c, len: 266 aa. Probable thyA, thymidylate synthase (EC 2.1.1.45). Highly similar to many thymidylate synthases involved in deoxyribonucleotide biosynthesis including: Escherichia coli SW:TYSY_ECOLI (P00470) (264 aa), Fasta scores: E(): 0, 66.3% identity in 261 aa overlap and Mycobacterium tuberculosis Rv2764c SW:TYSY_MYCTU (O33306) (263 aa), Fasta scores: E(): 0, 85.5% identity in 262 aa overlap. Contains Pfam match to entry PF00303 thymidylat_synt, Thymidylate synthase. Contains PS00091 Thymidylate synthase active site.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18330301833830-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1519c|thyA
VLIATPYEDLLRLVLDCGVAKMDRTGTGTRSLFGQQLRYDLSVGFPLVTTKKVHFKSVVYELLWFLRGDSNVAWLHEHGVNIWDEWASSTGDLGPIYGVQWRSWPTSSGDYIDQISTALDLLRTEPDSRRIIVSAWNVGEIPQMALPPCHAFFQFYVAQGRLSCQLYQRSADMFLGVPFNIASYALLTHMMAAQSGLLVGEFVWTGGDCHIYDNHVEQVQLQLSREPRAYPELFLAQRDSIFDYVYEDVVVTNYDPHPAIKAPVAI
      
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