Gene ML1543c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameeccC5
Gene length4158 bp
IdentifierML1543c
Location 1862221 bp
Protein summary information
Molecular mass152779.0 Da
Isoelectric point5.25
Protein length1386 amino acids
Structural information
PFAMPF01580
Orthologs
M. tuberculosis H37RvRv1783
M. lepromatosis Mx1-22AMLPM_1543
Cross-references
UniProtQ7AQ47
Gene OntologyDna binding, Cell cycle, Cell division, Chromosome segregation, Integral to membrane, Nucleoside-triphosphatase activity, Atp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductESX CONSERVED COMPONENT ECCC5. PROBABLE MEMBRANE PROTEIN (SpoIIIE FAMILY)
CommentsML1543c, len: 1385 aa. esx conserved component, probable membrane protein (SpoIIIE-family). Highly similar to the C-terminus of Rv1784 hypothetical protein TR:O53935 (EMBL:AL022021) (932 aa), Fasta scores: E(): 0, 87.8% identity in 932 aa overlap. The N-terminus is similar to Rv1783 conserved membrane protein TR:O53934 (EMBL:AL022021) (435 aa), Fasta scores: E(): 0, 87.1% identity in 395 aa overlap. The C-terminus is also similar to several others e.g. Bacillus subtilis SP3E_BACSU (P21458) (787 aa), Fasta scores: E(): 3e-09, 24.0% identity in 391 aa overlap stage III sporulation protein E (SpoIIIE) a protein required for chromosome segregation. Also similar to ML2535 from M. leprae. Contains possible N-terminal membrane spanning hydrophobic domains. Contains 2 Pfam matches to entry PF01580 FtsK_SpoIIIE, FtsK/SpoIIIE family. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS18622211866378-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1543c|eccC5
VKRGFARPTPEKAPVIRPENIVLPTPLSIPPPEGKPWWVIVIGVVVIGLVGGMVAMTFASGSRVFGGAGSIFPLFMIGGVAMMMFSGRMGGQQQMSRPKLDAMRAQFMLMLDMLREAANESADSMDANYRWFHPAPTTLAAAVGSSRMWERKPDGKDLNFCVVRVGVGMTRPEVTWGEPQNMPTDIELEPVTGKALQEFGRYQSIVYNLPKMVSLLVEPWYALIGDREQTLGLMRSIICQLTFSHGPDHVQMVVVSSDLEQWDWVKWLPHFGDPRRQDAAGNARMVYSSVREFATEQAELFAGRGSFTPRHASSSAQTPTPHHLIVADVVDPEWEYVISVEGIDGVTFFDLTGSSMWTVVPKRTLRFDEKGVIDALPRDRDTWMVIDDKPWFFALADQLSFAEAEEFAQKLAHWRPAEAYEEIGQRVAHIGARDILSYYGIGDPSAIDFDALWNSRTDAMGKSRLRVPFGNRSDNGELLFLDMKSLDEGGDGPHGVMSGTTGSGKSTLVRTVIESLMLAHPPEELQFVLADLKGGSAVKPFAGVPHVSRIITDLEEDQVLMERFLDALWGEIARRKAVCDNAGVDDAKEYNSVRTRMRARGQDMPALPMLVVVIDEFYEWFRIVPTAVDVLDSIGRQGRAYWIHLMMASQTIESRAEKLMENMGYRLVLKARTAGAAQAAGVPNAVNLPAQAGLGYFRKSLEDVIRFQAEFLWRDYFRGVTLDGEEQPVLVHNIDYVRPQLFTNLFTPLEVSVGGPEVDAEAVFANAQEFDEEIAEEEAEGGVRTPKIGTVIIDQLRRIDFEPYRLWQPPLTQPVAIDDLVNRFLGHPWQKDYGSARNLVFPIGVIDRPFKHDQPAWTVDTSGPGSNVLVLGAGGSGKTTALQTIICSAALTHTPEQVQFYCLGYSGTALTTVAHLPHVGEVAGPTDPYGVRRTVAELLALVRDRKRSFLEHGIASMEVFRRRKFGGELGPVPNDGFGDVYLVIDNYRALVEENEVLIEQVNQIINQGPSFGVHVVVTADRESELRPQVRSGFGSRVELRLAAVEDAKLVRSRFAKDVPVQSGRGMVAVNYVRLDSDPQAGLHTLVARPALANTPANVFESDSVVAPVSRLTSAQAPPVRRLPARFGMEQVRERAVRDTRQGVGVGGIAWAISELDLQPVYLNFAENAHLMITGRRECGRTTVLATIMSEIGRLYAPGGTSAPPTSERSAQVWLIDPRRQLLTMLGSNYMEKFAYNLDGVSAMVGELAALLASREPPPDLSAEELLSRSWWSGPEIFLIIDDIQQLPPSFDSPLQKVVPWVTRAGDVGLHVIATRTFGGWSSAGSDPMLRALHQANAPLLVMDADPDEGFIRGKMKGGPLPRGRGLLMAEDTGVLVQVAETDMRR
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