Gene ML1615c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametrmD
Gene length717 bp
IdentifierML1615c
Location 1938746 bp
Protein summary information
Molecular mass26228.9 Da
Isoelectric point6.51
Protein length239 amino acids
Structural information
PFAMPF01746
Orthologs
M. tuberculosis H37RvRv2906c
M. lepromatosis Mx1-22AMLPM_1615
Cross-references
UniProtO33017
Gene OntologyCytoplasm, Trna (guanine-n1-)-methyltransferase activity, Trna modification, Rna binding
Enzyme Classification2.1.1.31
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRNA (GUANINE-N1)-METHYLTRANSFERASE TRMD (M1G-METHYLTRANSFERASE) (TRNA [GM37] METHYLTRANSFERASE)
CommentsML1615c, len: 238 aa. Probable trmD, tRNA (guanine-N1)-methyltransferase (EC 2.1.1.31). Highly similar to many tRNA (guanine-N1) methyltransferases including: Escherichia coli SW:TRMD_ECOLI (P07020) (255 aa), Fasta scores: E(): 5.4e-33, 43.5% identity in 230 aa overlap and Mycobacterium tuberculosis Rv2906c SW:TRMD_MYCTU (Q10797) (230 aa), Fasta scores: E(): 0, 87.7% identity in 227 aa overlap. Contains Pfam match to entry PF01746 tRNA_m1G_MT, tRNA (Guanine-1)-methyltransferase.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19387461939462-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1615c|trmD
MKIDIVTIFPAYLDPLRQSLPGKAIESGLVDVQVHDLRRWTHDVHHSVDDVPYGGGPGMVMKAPVWGEALDEICFDETLLVIPTPAGALFTQATAQCWSTERHLVFACGRYEGIDQRVVDDAVRRMRVEEVSIGDYVLPGGESAAVVMIEAVLRLVAGVLGNPASHRDDSHSPDLGRLLEGPSYTRPPTWRGLDVPPVLLSGDHARIAAWRREASLRRTRKRRPDLSGARFVWGLGLS
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