Gene ML1630c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameglnE
Gene length3015 bp
IdentifierML1630c
Location 1959892 bp
Protein summary information
Molecular mass110206.0 Da
Isoelectric point6.77
Protein length1005 amino acids
Structural information
PFAMPF03710, PF08335
Orthologs
M. tuberculosis H37RvRv2221c
M. lepromatosis Mx1-22AMLPM_1630
Cross-references
UniProtQ9CBT4
Gene OntologyAtp binding, [glutamate-ammonia-ligase] adenylyltransferase activity
Enzyme Classification2.7.7.42
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionREGULATORY PROTEIN INVOLVED IN THE REGULATION OF GLUTAMINE SYNTHETASE ACTIVITY. ADENYLYLATION AND DEADENYLYLATION OF GLUTAMINE SYNTHETASE. POSSIBLY REGULATES GLNB|Rv2919c [CATALYTIC ACTIVITY: ATP + [L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)] = PYROPHOSPHATE + ADENYLYL-[L-GLUTAMATE:AMMONIA LIGASE (ADP-FORMING)]].
ProductGLUTAMATE-AMMONIA-LIGASE ADENYLYLTRANSFERASE GLNE (Glutamine-synthetase adenylyltransferase)
CommentsML1630c, len: 1004 aa. Probable glnE, glutamate-ammonia-ligase adenyltransferase (EC 2.7.7.42). Similar to several glutamate-ammonia-ligase adenylyltransferases including: Escherichia coli SW:GLNE_ECOLI (P30870) (946 aa), Fasta scores: E(): 2.4e-21, 28.2% identity in 929 aa overlap and Mycobacterium tuberculosis Rv2221c SW:GLNE_MYCTU (Q10379) (994 aa), Fasta scores: E(): 0, 82.8% identity in 998 aa overlap.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19598921962906-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1630c|glnE
VCCTTVVVVRKPATERLKRPSVGRLGLFDPHAAENLALLGWYDYDCREHVDLLWSLSRAPDADAVLRPMVRLFENPATGWDELNAALLTDRGLRGRLFAVLGSSLALGDHLVAHPQSWKLLRGRVSLPSRTQLHQAFDECVSNFGDDPLDAPDSVLPRLRTLYCDQLLVLAALDLAATVEDEPVLPFTLVAAQLADIADAAMATALRVAEKIVCGDRTPPRLAVIAMGKWGARELNYVSDVDIIFVAEQADPLSTRVASEMMRVASEAFFQVDAGLRPEGRNGELVRTVESHIAYYQRWAKTWEFQALLKARSAVGDAELGERYLAALMPMVWAACERADFVAEVQAMRRRVEQLVPADVRGRELKLGSGGLRDVEFAVQLLQLVHGRSDESLHVVSTVDALAALGEGGYIGREDAANLTASYEFLRLLEHRLQLQRLKRTHLLPEDGDEEAVRWLARAAHIRPDGRHDAAGVLREELKNQNLRVSQLHAKLFYQPLLESIGPASLEIRHGMTSEAAERQLATLGYEGSQTALKHISALVNQSGRRGRVQSVLLPRLLNWMSYAPDPDGGLLAYRRLSEALSAETWYLSTLRDKPAVARRLMHVLGTSVYVPDLLMRAPEVIQSYGDGLAGPKLLEAEPAMVARALITSAGRHTDPIRAIDAARSLRRRELARVGSADLLGLLEVTEVCKALTSVWVAVLQAALDAVIRAYLPDGDKAPAAIAVIGMGRLGGAELGYGSDADVMFVCEPAIGVEDAQALRWSGMIAERVCRLLRTPSVDPPLDVDANLRPEGRNGPLVRTLGAYAAYYAQWAQPWEIQALLRAHAVAGDADLGQRFLLMADKMRYPPDGVSAEAVREIRRMKARVEAERLPRGADPHTHTKLGRGGLADIEWTVQLMQLRHAHELPALHKTSTLESLDAIAAANLIPEADVDLLRQAWLTATRARNALVLVRGKTTDQLPGPGRQLNAVAVAAGWPSDDGSEFLDNYLRVTRRAKTFVRKVFGS
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