Gene ML1635 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namepanB
Gene length861 bp
IdentifierML1635
Location 1969135 bp
Protein summary information
Molecular mass30011.2 Da
Isoelectric point5.33
Protein length287 amino acids
Structural information
PFAMPF02548
Orthologs
M. tuberculosis H37RvRv2225
M. lepromatosis Mx1-22AMLPM_1635
Cross-references
UniProtQ9CBT0
Gene OntologyCytoplasm, Magnesium ion binding, Pantothenate biosynthetic process, 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Enzyme Classification2.1.2.11
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductProbable 3-methyl-2-oxobutanoate hydroxymethyltransferase PanB
CommentsML1635, len: 286 aa. Probable panB, 3-methyl-2-oxobutanoate hydroxymethyltransferase (EC 2.1.2.11). Highly similar to 3-methyl-2-oxobutanoate hydroxymethyltransferases from Escherichia coli SW:PANB_ECOLI (P31057) (264 aa), Fasta scores: E(): 0, 45.9% identity in 257 aa overlap and Mycobacterium tuberculosis Rv2225 SW:PANB_MYCTU (Q10505) (281 aa), Fasta scores: E(): 0, 82.6% identity in 287 aa overlap. Also similar to ML1718 a possible pseudogene similar to M. tuberculosis panB.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS19691351969995+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1635|panB
MSEQNVNVYGADPSTSSIQSIQRTKIRTKHLQKMKAEGHKWAMLTAYDYSTARVFDEAGIPVLLVGDSAANVVYGYDTTVPVSADELLPLVRGVVRGAGHALVVADLPFGSYEPGPTAALAVATRFMKEGGAHAVKLEGGQRVAEQIACLTAAGIPVMAHIGFTPQSVNSLGGFRVQGRGGDAEQTVADAVAVAEAGAFSVVMEMVPTELATQITGKLTIPTIGIGAGLNCDAQVLVWQDMAGLSSGKVARFVKQYADIAGELRRAAMQYAEEVASAVFPAEEHCF
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