Gene ML1663c (coaD)
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN THE COENZYME A (CoA) BIOSYNTHESIS (AT THE FOURTH STEP). REVERSIBLY TRANSFERS AN ADENYLYL GROUP FROM ATP TO 4'-PHOSPHOPANTETHEINE, YIELDING DEPHOSPHO-CoA (DPCOA) AND PYROPHOSPHATE [CATALYTIC ACTIVITY: ATP + PANTETHEINE 4'-PHOSPHATE = DIPHOSPHATE + DEPHOSPHO-CoA]. |
| Product | PROBABLE PHOSPHOPANTETHEINE ADENYLYLTRANSFERASE KDTB (PANTETHEINE- PHOSPHATE ADENYLYLTRANSFERASE) (PPAT) (DEPHOSPHO-CoA PYROPHOSPHORYLASE) |
| Comments | ML1663c, len: 157 aa. Probable kdtB (alternate gene name: coaD), phosphopantetheine adenylyltransferase (EC 2.7.7.3). Highly similar to many phosphopantetheine adenylyltransferases involved in coenzyme A biosynthesis, including: Escherichia coli SW:COAD_ECOLI (P23875) (159 aa), Fasta scores: E(): 5.9e-25, 43.5% identity in 154 aa overlap and Mycobacterium tuberculosis Rv2965c SW:COAD_MYCTU (Q50452) (161 aa), Fasta scores: E(): 0, 85.6% identity in 153 aa overlap. Contains Pfam match to entry PF01467 Cytidylyltransf, Cytidylyltransferase. Note previously known as coaD. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2005139 | 2005612 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1663c|kdtB
VVCPGSFDPVTLGHIDVFERAAAQFDEVVVAILINPVKKGMFDLDERIAMINESTMHLPNLRVEAGEGLVVALVRSRGMTAIVKGLRTGVDFEYELQMAQMNKHIAGVDTFFVATAPRYSFVSSSLVKEVAMLGGDVSELLPESVNRRFREKMSGTS
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