Gene ML1671c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | CRITICAL ROLE IN RECOMBINATION AND DNA REPAIR. HELP PROCESS HOLLIDAY JUNCTION INTERMEDIATES TO MATURE PRODUCTS BY CATALYSING BRANCH MIGRATION. HAS A DNA UNWINDING ACTIVITY CHARACTERISTIC OF A DNA HELICASE WITH A 3' TO 5' POLARITY. RECG UNWIND BRANCHED DUPLEX DNA (Y-DNA). |
| Product | PROBABLE ATP-DEPENDENT DNA HELICASE RECG |
| Comments | ML1671c, len: 743 aa. Probable recG, ATP-dependent DNA helicase (EC 3.6.1.-). Highly similar to many ATP-dependent DNA helicases including: Staphylococcus aureus SW:RECG_STAAU (O50581) (686 aa), Fasta scores: E(): 2e-24, 35.7% identity in 701 aa overlap and Mycobacterium tuberculosis Rv2973c SW:RECG_MYCTU (P95122) (737 aa), Fasta scores: E(): 0, 79.4% identity in 744 aa overlap. Contains Pfam match to entry PF00271 helicase_C, Helicases conserved C-terminal domain. Contains Pfam match to entry PF00270 DEAD, DEAD/DEAH box helicase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2014730 | 2016961 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1671c|recG
MVSLSDRLDYIVGAKAADSLDEVFGIRTVDDLLRHYPRSYTKGATVRGAQDERPEAGEHITIVDVITEAVTLPMKKDSKKKYLRLTVGSGRNKVIATFFNAGYISKGLTKDTRVMLSGEVGFFRGVMQLTHPAFLILDSPDGRNRGSSSLRRIADASQAVSGEVLMSAFERRFFPIYPASTKLQSWDIYACVRQVLEVLDPVADPLPADLRAKHGLVSEDEALRAIHLAESESDRRRARERLTFDEAVGLQWALVTRRHGELSESGPSAPPRSDGLMAELMRRLPFELTEGQREVRDVLSDGLAATRPLNRLLQGEVGSGKTIVAVLAMLQMIDAGYQCVLLAPTEVLAAQHLLSIRDVLGPLGMGCQLGGAENATQVALLTGSMTMAQKKKVRADIFSGQTGIVIGTHALLQDAIEFHNLGMVVVDEQHRFGVEQRDQLRTKARTGIMPHLLVMTATPIPRTVALTVYGDLEMSTLRELPRGRQPITSNVIFVKDKPGWLDRAWQRILEEVAAGRQAYVVAPRIDETEDPQKGGQNSRPSETADGLYARLRSGELANVRLALMHGRLSADEKDAAMMAFRAGEIDVLVCTNVIEVGVDVPNATIMLVMDADRFGISQLHQLRGRIGRGTHPSLCLLASWVSPGSPAGRRLCAVAETMDGFALADLDLKERREGDVLGRNQSGKAITLRMLSLAEHQVFIEAARDFCTRAYEYPHLGLAPHPGLADLAARFIDTDRIEYLGKS
Bibliography
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