Gene ML1676c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namethiL
Gene length978 bp
IdentifierML1676c
Location 2020081 bp
Protein summary information
Molecular mass33331.6 Da
Isoelectric point5.13
Protein length326 amino acids
Structural information
PFAMPF00586, PF02769
Orthologs
M. tuberculosis H37RvRv2977c
M. lepromatosis Mx1-22AMLPM_1676
Cross-references
UniProtQ9CBS2
Gene OntologyThiamine-phosphate kinase activity, Thiamine biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE THIAMINE-MONOPHOSPHATE KINASE THIL (THIAMINE-PHOSPHATE KINASE)
CommentsML1676c, len: 325 aa. Probable thiL, thiamine-monophosphate kinase (EC 2.7.4.16). Similar to several thiamine-monophosphate kinases including: Escherichia coli SW:THIL_ECOLI (P77785) (325 aa), Fasta scores: E(): 1.1e-18, 35.3% identity in 278 aa overlap and Mycobacterium tuberculosis Rv2977c TR:P95118 (P95118) (333 aa), Fasta scores: E(): 0, 80.9% identity in 314 aa overlap. Contains Pfam match to entry PF00586 AIRS, AIR synthase related protein.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20200812021058-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1676c|thiL
VCNHECGALGESVTLEQLGEFAVIDRLVRGRRQPAVVALGPGDDAAVVTASDGRIVVSTDVLVQDRHFRLDWSTPHDVGRKAIAQNAADIEAMGARATTFVVGLGAPGDTPVAQVDALVDGLWDEAGRIGAGIVGGDLVSCPQWVLSVTVLGDLDGRAPVLRSGAKNGSMVAVAGALGRSAAGYALWHKGIDGFDDLRRRHLVPEPPYGKGVAAAACGAQAMIDVSDGLIADLRHVARASGVSIDLSTAALAADHAALIAAATAVGGDPWPWVLGGGEDHALVACFAGTALSGWRIIGRVFDGPARVLVDGQEWRGHAGWQSFGG
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