Gene ML1678c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameddlA
Gene length1155 bp
IdentifierML1678c
Location 2021826 bp
Protein summary information
Molecular mass40948.7 Da
Isoelectric point4.81
Protein length385 amino acids
Structural information
PFAMPF01820, PF07478
Orthologues
M. tuberculosisRv2981c
Cross-references
UniProtQ9CBS0
Gene OntologyD-alanine-d-alanine ligase activity, Cell wall, GO:0007047, Cytoplasm, Magnesium ion binding, Manganese ion binding, Peptidoglycan biosynthetic process, Regulation of cell shape, Atp binding
Enzyme Classification6.3.2.4
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE D-ALANINE--D-ALANINE LIGASE DDLA (D-ALANYLALANINE SYNTHETASE) (D-ALA-D-ALA LIGASE)
CommentsML1678c, len: 384 aa. Probable ddlA, D-alanine-D-alanine ligase A (EC 6.3.2.4). Highly similar to D-alanine--D-alanine ligase A from many including: Salmonella typhimurium SW:DDLA_SALTY (P15051) (363 aa), Fasta scores: E(): 0, 43.5% identity in 368 aa overlap and Mycobacterium tuberculosis Rv2981c SW:DDL_MYCTU (P95114) (373 aa), Fasta scores: E(): 0, 81.7% identity in 367 aa overlap. Contains Pfam match to entry PF01820 Dala_Dala_ligas, D-ala D-ala ligase. Contains PS00844 D-alanine--D-alanine ligase signature 2. Contains PS00843 D-alanine--D-alanine ligase signature 1.
Functional categoryCell wall and cell processes
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20218262022980-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1678c|ddlA
VNVYQRPLMPWLPSGGRVRVAVVFGGRSNEHAVSCLSAGSILRNLDRQRFDVVAVGITPEGTWMLTDPNPDALAIANRQLPAVSCESGIELTLPADPRRSGQLVSLSHGAGLGAGEVLTSVDVVFPVLHGPYGEDGTIQGLLELARVPYVGAGVLASAAGMDKEFTKKLFAAEGLPLSAYTVLRPLRPTLHRQECERLSLPVFVKPARGGSSIGISRVSSWGQLPSAIAYARRHDPKVIVEAAVNGRELECGVLEMPDGTVAASAVGEIRVAGVSGSEDSFYDFTTKYLDDAAELDVPAKVDDDVADEVRQLAIQAFRAIDCQGLARVDFFLTDDGPVINEINTMPGFTMTSMYPKLWAVSSVDYPTLLATMVDTALARGVGMR
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