Gene ML1685c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameleuC
Gene length1458 bp
IdentifierML1685c
Location 2030179 bp
Protein summary information
Molecular mass52122.1 Da
Isoelectric point5.45
Protein length486 amino acids
Structural information
PFAMPF00330
Orthologs
M. tuberculosis H37RvRv2988c
M. lepromatosis Mx1-22AMLPM_1685
Cross-references
UniProtO33123
Gene Ontology4 iron, 4 sulfur cluster binding, Iron ion binding, Leucine biosynthetic process, 3-isopropylmalate dehydratase activity
Enzyme Classification4.2.1.33
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE 3-ISOPROPYLMALATE DEHYDRATASE (LARGE SUBUNIT) LEUC (ISOPROPYLMALATE ISOMERASE) (ALPHA-IPM ISOMERASE) (IPMI)
CommentsML1685c, len: 485 aa. Probable leuC, 3-isopropylmalate dehydratase large subunit (EC 4.2.1.33). Highly similar to many 3-isopropylmalate dehydratase large subunits involved in leucine biosynthesis, including: Escherichia coli SW:LEU2_ECOLI (P30127) (465 aa), Fasta scores: E(): 0, 61.3% identity in 463 aa overlap and Mycobacterium tuberculosis Rv2988c SW:LEU2_MYCTU (O53237) (473 aa), Fasta scores: E(): 0, 88.7% identity in 471 aa overlap. Contains Pfam match to entry PF00330 aconitase, Aconitase family (aconitate hydratase). Contains PS01244 Aconitase family signature 2. Contains PS00450 Aconitase family signature 1.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20301792031636-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1685c|leuC
LEMDNERKQVGGARKPRTLAEKVWDDHVVVAGQGYHQDRGPDLIYIDLHLVHEVTSPQAFDGLRLAGRWVRRPDLTVATEDHNVPTVDIDKPIADPVSRIQVETLRRNCAEFGVRLHPMGDIEQGIVHVVGPQLGLTQPGMTIVCGDSHTSTHGAFGAIAMGIGTSEIEHVLATQTLPLRPFKTMAVTVDGRLPAGVTAKDIILALIAKIGTGGGQGYVLEYRGSVIESMSMEGRMTICNMSIEAGARAGMVAPDETTYEFLRDRPHAPTGKQWDAAVAYWQQLRTDDDAVFDTEVYLDATSLSPFVTWGTNPGQGVPLAASVPDPELMIDDVARQAAEKALAYMDLRPGTPMRDIAVDAVFVGSCTNGRIEDLRLVADVLRGHKVADGVRMLIVPGSMRVRAQAEAEGLGEIFITAGAQWRQPGCSMCLGMNPDQLAPGERCAATSNRNFEGRQGKGGRTHLVSPAVAAATAVRGTFSAPADLN
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