Gene ML1700c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU- TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. |
| Product | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT B) GATB (Glu-ADT SUBUNIT B) |
| Comments | ML1700c, len: 509 aa. Probable gatB, glutamyl-tRNA(Gln) amidotransferase, subunit B (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit B) including: Bacillus subtilis SW:GATB_BACSU (O30509) (269 aa), BlastP Expect 8.6 and Mycobacterium tuberculosis Rv3009c SW:GATB_MYCTU (O53256) (509 aa), Fasta scores: E(): 0, 88.4% identity in 509 aa overlap. Contains Pfam match to entry PF01162 PET112, PET112 family. Contains PS01234 PET112 family signature. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2050127 | 2051656 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1700c|gatB
MTVVSGASKASGADLLDYDVVVARFDPVFGLEVHVELSTVTKMFCGCATTFGAEPNTQVCPVCLGLPGSLPVLNRAAVQSAIRIGLALNCEIVPWCRFARKNYFYPDVPKNYQISQYDEPIAINGYLEVPLEDDTTWRVEIERAHMEEDTGKLTHLGSETGRIYGATTSLIDYNRAGVPLIEIVTKPIEGAGVRAPQIARAYVKALQDLLRTLDVSDVRMDQGSMRCDANVSLKPIGTVEFGTRSEIKNVNSLKSVEMAVRYEMQRQGAILVSGGRIAQETRHFHEDGYTSPGRAKETAQDYRYFPDPDLEPVAPSRELVEQLRQTIPELPWLSRKRIQQEWGISDEVMRDLVNAGAVELVAATVKNGASSEQARAWWGNFLVQKANEANITLDELAITPAQVAVVVALVDEGKLSIRLARQVVEGVLAGEGEPEQVMVDRDLALVRDDSVMQAAVDEALAADPDVAEKIRGGKVAAAGAIVGAVMKTTRGQADAARVRELVLAICGQG
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