Gene ML1702c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU-TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. |
| Product | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) |
| Comments | ML1702c, len: 497 aa. Probable gatA, glutamyl-tRNA(Gln) amidotransferase, subunit A (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit A) including: Bacillus subtilis SW:GATA_BACSU (O06491) (485 aa), Fasta scores: E(): 0, 50.8% identity in 476 aa overlap and Mycobacterium tuberculosis Rv3011c SW:GATA_MYCTU (O53258) (494 aa), Fasta scores: E(): 0, 88.5% identity in 494 aa overlap. Contains Pfam match to entry PF01425 Amidase, Amidase. Contains PS00017 ATP/GTP-binding site motif A (P-loop). BELONGS TO THE AMIDASE FAMILY |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2053124 | 2054617 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1702c|gatA
MIGSLHEIIRLDASTLAAKIVAKELSSVEITQACLDQIEATDDTYRAFLHVAAEKALSAAAAVDKAVAAGGQLSSTLAGVPLALKDVFTTVDMPTTCGSKILQGWHSPYDATVTTRLRAAGIPILGKTNMDEFAMGSSTENSAYGPTRNPWNVDRVPGGSGGGSAAALAAFQAPLAIGSDTGGSIRQPAALTATVGVKPTYGTVSRYGLVACASSLDQGGPCARTVLDTALLHAVIAGHDARDSTSVEAAVPDIVGAAKAGESGDLHGVRVGVVRQLRGEGYQSGVLASFQAAVEQLIALGATVSEVDCPHFDYALAAYYLILPSEVSSNLARFDAMRYGLRVGDDGSRSAEEVIALTRAAGFGPEVKRRIMIGAYALSAGYYDSYYSQAQKVRTLIARDLDKAYRSVDVLVSPATPTTAFSLGEKADDPLAMYLFDLCTLPLNLAGHCGMSVPSGLSSDDDLPVGLQIMAPALADDRLYRVGAAYEAARGPLPSAI
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