Gene ML1703c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | COMPONENT OF THE TRANSLATIONAL APPARATUS. FURNISHES A MEANS FOR FORMATION OF CORRECTLY CHARGED GLN-TRNA(GLN) THROUGH THE TRANSAMIDATION OF MISACYLATED GLU- TRNA(GLN) IN ORGANISMS WHICH LACK GLUTAMINYL-TRNA SYNTHETASE. THE REACTION TAKES PLACE IN THE PRESENCE OF GLUTAMINE AND ATP THROUGH AN ACTIVATED GAMMA-PHOSPHO-GLU-TRNA(GLN) [CATALYTIC ACTIVITY: ATP + L-GLUTAMYL-TRNA(GLN) + L-GLUTAMINE = ADP + PHOSPHATE + L-GLUTAMINYL-TRNA(GLN) + L-GLUTAMATE]. |
| Product | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT C) GATC (Glu-ADT SUBUNIT C) |
| Comments | ML1703c, len: 99 aa. Probable gatC, glutamyl-tRNA(Gln) amidotransferase, subunit C (EC 6.3.5.-). Highly similar to many glutamyl-tRNA(Gln) amidotransferases (subunit C) including: Bacillus subtilis SW:GATC_BACSU (O06492) (96 aa), Fasta scores: E(): 6.9e-08, 37.9% identity in 95 aa overlap and Mycobacterium tuberculosis Rv3012c SW:GATC_MYCTU (O53259) (99 aa), Fasta scores: E(): 3.1e-28, 74.7% identity in 99 aa overlap. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2054614 | 2054913 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1703c|gatC
VSPISRDEVLHLARLTRLVLTDTELASFSSQLDVILAHVSQIQAVDVTGVEPTDNPLKYVNITRPDETVPCLTQQQALAEAPEAIYGRFVVPQILGDNK
Bibliography
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