Gene ML1705c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THIS PROTEIN CATALYZES THE FORMATION OF PHOSPHODIESTER LINKAGES BETWEEN 5'-PHOSPHORYL AND 3'-HYDROXYL GROUPS IN DOUBLE-STRANDED DNA USING NAD AS A COENZYME AND AS THE ENERGY SOURCE FOR THE REACTION. IT IS ESSENTIAL FOR DNA REPLICATION AND REPAIR OF DAMAGED DNA [CATALYTIC ACTIVITY: NAD(+) + (DEOXYRIBONUCLEOTIDE)(N) + (DEOXYRIBONUCLEOTIDE)(M) = AMP + NICOTINAMIDE NUCLEOTIDE + (DEOXYRIBONUCLEOTIDE)(N+M)]. |
| Product | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) |
| Comments | ML1705c, len: 694 aa. Probable ligA, DNA ligase (EC 6.5.1.2). Highly similar to many DNA ligases essential for DNA replication and repair, including: DNLJ_ECOLI and Mycobacterium tuberculosis Rv3014c SW:DNLJ_MYCTU (O53261) (691 aa), Fasta scores: E(): 0, 84.7% identity in 687 aa overlap. Contains Pfam match to entry PF01653 DNA_ligase_N, NAD-dependent DNA ligase. Contains Pfam match to entry PF00533 BRCT, BRCA1 C Terminus (BRCT) domain. Contains PS01055 NAD-dependent DNA ligase signature 1. |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2055751 | 2057835 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1705c|ligA
VSSPEADPIGPEVLQQWRKLTEEVREHQFRYYVRDAPIISDAEFDALLDRLTVLEEQHPELCTPDSPTQLVGGAGFMTDFVATEHLERMFSLDNAFSGDELNAWVTRIRAEIGNDAHYLCELKIDGVALSLVYRDGRLTRATTRGDGRTGEDVTLNARTIEDVPERLTVSDIYPLPEVLEVRGEVFFRVVDFQALNTSLVEEGKNPFANPRNSAAGSLRQKDPAVTAHRKLRMICHGLGHIEGFRPATQHQAYLALRDWGLPVSEHTTLVNDIAGVQGCIAYWAEHRHEVDHEIDGIVVKIDEVTLQRRLGSTSRAPRWAIAYKYLPEEAQTKLLDIRVNVGRTGRVTPFAFMTPVKVAGSTVGQATLHNPSEVKRKGVLIGDTVVIRKAGDVIPEVLGPVVDLRDGSEREFVMPTTCPECGTTLAPEKEGDADIRCPNARSCPGQLRERVFHVASRSALDIQGLGYEAGVALLAAQVITSEGDLFTLTEKALLRTELFRNKAGELSANGKRLLVNVDKAKTAPLWRVLVALSIRHVGPTAARALATEFGSVDAILAASPEQLAAVEGVGTTIAAAVTEWFTVDWHRVIVNKWRAAGVRMVDERDTSVLPTCEGLTIVVTGSLAGFSRDDAKEAIVARGGKVAGSVSKKIAYVVVGDLPGYKYDKAVELGVPILNEDGFRLLLEQGPPVQQVVD
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