Gene ML1707c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametrmU
Gene length1077 bp
IdentifierML1707c
Location 2059823 bp
Protein summary information
Molecular mass37701.9 Da
Isoelectric point7.5
Protein length359 amino acids
Structural information
PFAMPF03054
Orthologs
M. tuberculosis H37RvRv3024c
M. lepromatosis Mx1-22AMLPM_1707
Cross-references
UniProtO33099
Gene OntologyCytoplasm, Trna (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity, Trna binding, Trna modification, Atp binding
Enzyme Classification2.8.1.-
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
Productprobable tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase TrmU
CommentsML1707c, len: 358 aa. Probable trmU, tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase (EC 2.1.1.61). Highly similar to many proposed tRNA (5-methylaminomethyl-2-thiouridylate) -methyltransferases including: Escherichia coli SW:TRMU_ECOLI (P25745) (368 aa), Fasta scores: E(): 0, 35.6% identity in 362 aa overlap and Mycobacterium tuberculosis Rv3024c SW:TRMU_MYCTU (O53271) (367 aa), Fasta scores: E(): 0, 85.2% identity in 357 aa overlap.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20598232060899-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1707c|trmU
VKVLAAMSGGVDSSVAAARMVDAGHDVVGVHLALSTVSGTLRTGSRGCCSKEDVSDARRVADVLGIPFYVWDFAEKFQEDVIDNFVSAYARGETPNPCVQCNQRIKFSALSVRALMLGFDTVATGHYARLSGGRLRRAVDRGKDQSYVLAVLTAQQLRHAAFPIGDTLKRQVRAEAARRGLLVADKPDSHGICFIPSGNTRAFLSECIGIRRGSVVDADGTVLAEHDGVHGFTVGQRKGLGIVGPGPNGRPRYVTAIDADTATVYVGDAADLGVHTLIGRAPVFTAGAAPLGPVQCVVQIRAHGETAVAVVELIGDELFVRLCEPLRGVARGQTLVLYRLDPDGDEVLGSATIASMSA
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