Gene ML1724c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameechA17
Gene length759 bp
IdentifierML1724c
Location 2080798 bp
Protein summary information
Molecular mass26586.2 Da
Isoelectric point4.3
Protein length253 amino acids
Structural information
PFAMPF00378
Orthologs
M. tuberculosis H37RvRv3039c
M. lepromatosis Mx1-22AMLPM_1724
Cross-references
UniProtQ9CBQ8
Gene OntologyMetabolic process, Isomerase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE ENOYL-CoA HYDRATASE ECHA17 (CROTONASE) (UNSATURED ACYL-CoA HYDRATASE) (ENOYL HYDRASE)
CommentsML1724c, len: 252 aa. Probable echA17, enoyl-CoA hydratase (EC 4.2.1.17). Similar to several proposed enoyl-CoA hydratases including: Rhizobium meliloti SW:ECHH_RHIME (Q52995) (257 aa), Fasta scores: E(): 1.8e-19, 34.7% identity in 225 aa overlap, Clostridium acetobutylicum SW:CRT_CLOAB (P52046) (261 aa), Fasta scores: E(): 1.7e-17, 27.9% identity in 240 aa overlap and Mycobacterium tuberculosis Rv3039c TR:O53286 (EMBL:AL021287) (254 aa), Fasta scores: E(): 0, 85.6% identity in 243 aa overlap. Also similar to ML2402 from M. leprae. Contains Pfam match to entry PF00378 ECH, Enoyl-CoA hydratase/isomerase family.
Functional categoryLipid metabolism
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS20807982081556-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1724c|echA17
MSEFVNIVVSDGSQDAGLAILLLSRPPTNAMTRQFYREIAMAADELGRRDDVAAVILFGGHDIFSAGDDMQELRTLTAVEAGVAAEVRRQAVDAVATIPKPTVAAITGYALGAGLTLALAADWRVSGDNVKFGATEILADLVPDGDGLARLTRVAGVSRAKDLVFSGRFFDAAEALALGLIDDMVAPDDVYDIAAAWARRFLDGLPHALAAAKAGINEVFDLEPAERIAAERRRYVEVFAAAQPSLLLGGCD
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