Gene ML1753c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1753c
Gene length3321 bp
IdentifierML1753c
Location 2123775 bp
Protein summary information
Molecular mass119375.0 Da
Isoelectric point5.04
Protein length1107 amino acids
Structural information
PFAMPF00196
Orthologs
M. tuberculosis H37RvRv1358
M. lepromatosis Mx1-22AMLPM_1753
Cross-references
UniProtQ9CBP3
Gene OntologyIntracellular, GO:0007242, Phosphorus-oxygen lyase activity, Regulation of transcription, dna-dependent, Sequence-specific dna binding, Sequence-specific dna binding transcription factor activity, Phosphorelay response regulator activity, Phosphorelay signal transduction system, Cyclic nucleotide biosynthetic process
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE TRANSCRIPTIONAL REGULATORY PROTEIN
CommentsML1753c, len: 1106 aa. Probable transcriptional regulatory protein. Highly similar to many from Mycobacterium tuberculosis e.g. probable transcriptional regulatory protein Rv1358 TR:Q11028 (EMBL:Z75555) (1159 aa), Fasta scores: E(): 0, 58.1% identity in 1084 aa overlap. Contains a putative helix-turn-helix motif situated between residues 1063..1084 (+2.87 SD). Contains a probable helix-turn-helix motif at aa 1063-1084 (Score 1080, SD +2.87) Contains Pfam match to entry PF00196 GerE, Bacterial regulatory proteins, luxR family. Contains PS00017 ATP/GTP-binding site motif A (P-loop). Contains PS00622 Bacterial regulatory proteins.
Functional categoryRegulatory proteins
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21237752127095-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1753c|ML1753c
MYSLGEMQKPVPVGADYLASCLVARLRSTDVPTDLHRGCTVTLFLGDVEGLAELSETQPDEAADAIARLDCVVSEAVAAHGGVQQVVQGVRGNFLATFARASDATACALDLQLAPIVPVRFRIALHTGEVQISNDDVNNVVFMMVQAAGLLDLACGGQTVLSSITGDLVVDGLPADTWLVDLGSHLLRDLARPVRVMQLCHRNLRRNLHELGIRTVPGGPSLPVPLTTFVGRAAQIKELQELLTEKRLLTLVGPGGVGKTRLALQVVARVADEFSGELSYFDLAPDTDHDIFPITVLDNLRRCIGDRRMLMVLDNCEYLLDVCANVMTTLLGACPSLTILATSREPIGVAGEVIWRVSMLSPADEAVELFTERAALVQPGFSVTDGNRQIVTEICQRLDGMPLAIELAAARIRTLSLTEIADGLDDRFRLLTGGARTAVRRQQTLRASMDWSYALLTESERALFRRLSAISGTFDLKVAYAVGHDDLEEPDQVFDRLTMLIDKSLVIVEGRQGGSRYRLLETVRQYAMKKLEESNEVDLVLARHRDHYMALGALLDTPGDIDHEQLVEQVETELDNLRSAFAWSRETGDIAGALQLASSLQPIWFGRGHMYEGLAWFDSIFEHKNIEHLVAPKEVLARAVANKVMLHAILASSPPDGSDLVTQAQQALTMAREIGDSAVLARALTACGFSSGYDTEVARPYFAEAVELARTQGDKWTLSQIRLWGVVGFCVSGDPVALRAAAEAADDLAQEIGDRFVSLQCRLLLSIAQLWQGDMDGAIVRSGEVVAGAEAAHDTVTRTFGLYVQTRALVHRDVSAALVTAGLVVEAAAELSGVYQGIGYAAMVFAALAMGDVAAAVEASEACRPHLGADHGLVAIHLELMAAVALARGDVIVARRLADNSVSATTGWHQMAALTTRARIAMAQGEPELARADIHAALACGADIQASLGISDSMELLAELISQGDNHRQAGRLFGAASAQREKTGEVRFKVWDAGYESAVAVLRGAMGCKDFDSAWAEGAAMPIDDAITYAQRGRGNRKRPTTGWESLTPAEHNVIRLVSEGLDTKDIAARLFVSVRTVHTHLTRIYSKLGLTSRVQLVQEAARHN
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