Gene ML1756
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | INVOLVED IN TRANSPORT OF MULTIDRUGS (TETRAPHENYLPHOSPHONIUM, ERYTHROMYCIN, ETHIDIUM BROMIDE, ACRIFLAVINE, SAFRANIN O, PYRONIN Y, etc) ACROSS THE MEMBRANE (EXPORT): MULTIDRUGS RESISTANCE BY AN EXPORT MECHANISM (CONFERES RESISTANCE TO TOXIC COMPOUNDS BY REMOVING THEM FOR THE CELLS). RESPONSIBLE FOR THE TRANSLOCATION OF THE SUBSTRATE ACROSS THE MEMBRANE. |
| Product | MULTIDRUGS-TRANSPORT INTEGRAL MEMBRANE PROTEIN MMR |
| Comments | ML1756, len: 107 aa. Probable mmr, integral membrane multidrugs resistance transporter. Highly similar to several multidrug resistance proteins e.g. Escherichia coli quaternary ammonium compound-resistance protein SW: QACE_ECOLI and Mycobacterium tuberculosis Rv3065 SW:YU65_MYCTU (P95094) (107 aa), Fasta scores: E(): 1e-31, 79.0% identity in 105 aa overlap. Contains multiple possible membrane spanning hydrophobic domains. Contains Pfam match to entry PF00893 DUF7, Integral membrane protein. |
| Functional category | Cell wall and cell processes |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2131298 | 2131621 | + |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1756|mmr
VAYLFLFCAIFVEVVATTLLKSTEGFTRLVPTLACLAGYAVTFTLLALSISRGMKTDVAYALWSAIGTAAIVLIAVLFLDSPVSVAKVVGVALIIVGVITLNLADAH
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