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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
General annotation
TypeCDS
FunctionUnknown
ProductFERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE)
CommentsML1805c, len: 336 aa. Probable hemZ, ferrochelatase (EC 4.99.1.1). Similar to M. tuberculosis hemZ Rv1485 SW:HEMZ_MYCTU (P71765) (344 aa), Fasta scores: E(): 0, 76.8% identity in 336 aa overlap, and to many others e.g. Propionibacterium freudenreichii shermanii ferrochelatase SW:HEMZ_PROFR (P72183) (352 aa), Fasta scores: E(): 0, 38.9% identity in 311 aa overlap. Contains Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase. Contains PS00534 Ferrochelatase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21857852186795-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
       
Protein sequence
>Mycobacterium leprae TN|ML1805c|hemZ
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLALVNELQVELDLPVYFGNRNWEPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAIARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAASLPAALRSEARLVFTAHSVPVATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLASAGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLIDELTHDRVPVRVNGSDPVPGCLASINGVPCDLPHCVA
      
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