Gene ML1805c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namehemZ
Gene length1011 bp
IdentifierML1805c
Location 2185785 bp
Protein summary information
Molecular mass36314.2 Da
Isoelectric point5.6
Protein length337 amino acids
Structural information
PFAMPF00762
Orthologs
M. tuberculosis H37RvRv1485
M. lepromatosis Mx1-22AMLPM_1805
Cross-references
UniProtQ9CBM2
Gene OntologyFerrochelatase activity, Heme biosynthetic process, Iron ion binding, Cytoplasm
Enzyme Classification4.99.1.1
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductFERROCHELATASE HEMZ (PROTOHEME FERRO-LYASE) (HEME SYNTHETASE)
CommentsML1805c, len: 336 aa. Probable hemZ, ferrochelatase (EC 4.99.1.1). Similar to M. tuberculosis hemZ Rv1485 SW:HEMZ_MYCTU (P71765) (344 aa), Fasta scores: E(): 0, 76.8% identity in 336 aa overlap, and to many others e.g. Propionibacterium freudenreichii shermanii ferrochelatase SW:HEMZ_PROFR (P72183) (352 aa), Fasta scores: E(): 0, 38.9% identity in 311 aa overlap. Contains Pfam match to entry PF00762 Ferrochelatase, Ferrochelatase. Contains PS00534 Ferrochelatase signature.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21857852186795-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1805c|hemZ
MLFDAALLLSFGGPDGPEQVRPFLENVTRGCNVPPERLDEVTKHYLHFGGVSPINGINLALVNELQVELDLPVYFGNRNWEPYIEDSVVTMRDDGIRCAAVFITSAWSGYSSCTRYVEAIARARRRAGTGAPNLVKLRPYFDHPLFVEMFVDAITAAAASLPAALRSEARLVFTAHSVPVATDRRCGPALYSRQVGYAARLVAAGAGYADYDLTWQSRSGPPYVPWLAPDVGDQLMTLASAGTKAVIVCPIGFVADHIEVVWDLDHELRSQADAAGVAFARAATPNADRRFARLAASLIDELTHDRVPVRVNGSDPVPGCLASINGVPCDLPHCVA
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