Gene ML1812c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1812c
Gene length1440 bp
IdentifierML1812c
Location 2192605 bp
Protein summary information
Molecular mass50554.7 Da
Isoelectric point9.12
Protein length480 amino acids
Structural information
PFAMPF00877
Orthologs
M. tuberculosis H37RvRv1477
M. lepromatosis Mx1-22AMLPM_1812
Cross-references
UniProtQ9CBL5
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductHYPOTHETICAL INVASION PROTEIN
CommentsML1812c, len: 479 aa. Hypothetical Invasion protein. Possibly exported protein with unusually long signal sequence. Similar to M. tuberculosis Rv1477 TR:O53168 (EMBL:AL021184) (472 aa), Fasta scores: E(): 0, 78.8% identity in 480 aa overlap and to Listeria innocua protein p60 precursor (invasion-associated protein) SW:P60_LISMO (P21171) (484 aa), Fasta scores: E(): 1e-06, 23.8% identity in 491 aa overlap. Also similar to ML1811, ML1214 and ML0885 from M. leprae. Contains Pfam match to entry PF00877 NLPC_P60, NLP/P60 family.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS21926052194044-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1812c|ML1812c
MKRPRRGSVSRPTARFVRPAIPSLVSAALLVSLPVLATADPDGDNLGTLIADVAKVNQRLEDLGAAIETEEQSVNKAMVSVEMARDNAVAAEHDCEVSQQSVKDANTAINAAQHRFDSFAAATYMNGPSGSYLTATSPDDIIATATAARTLTASSQAVMANLQRARTEQVNKESAARLAKQKADKAADDAKASMDAAVAALTASKRKFDEQRDEVNRLAAERDEAQARLEVAQIAAATWVPGMGGHGTPPFGDRWEPGSPASAGPAGGRKWDGWDPTLPQVPSANVPGDPIAVINQVLGYAATSTQVTASMGRNFLQQLGILKPNDTGITNAPIGSTQGRIPRVYGRQASEYVIRRGISQIGVPYSWGGGNAAGPSRGIDSGAGITGFDCSGLVLYSFAGVGIRLPHYSGSQYNLGRKIPSAQMRRGDVIFYGPGGSQHVTIYLGHGQMLEAPDIGLRVRVAPVRTSGMTPYVVRYIEY
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