Gene ML1877c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nametuf
Gene length1191 bp
IdentifierML1877c
Location 2255797 bp
Protein summary information
Molecular mass43635.5 Da
Isoelectric point5.12
Protein length397 amino acids
Structural information
PFAMPF00009, PF03143, PF03144
Orthologs
M. tuberculosis H37RvRv0685
M. lepromatosis Mx1-22AMLPM_1877
Cross-references
UniProtP30768
Gene OntologyGtpase activity, Cytoplasm, Translation elongation factor activity, Translational elongation, Gtp binding
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE IRON-REGULATED ELONGATION FACTOR TU TUF (EF-TU)
CommentsML1877c, len: 396 aa. Probable tuf, iron-regulated elongation factor EF-Tu. Similar to M. tuberculosis elongation factor TU Rv0685 SW:EFTU_MYCTU (P31501) (396 aa), Fasta scores: E(): 0, 94.9% identity in 396 aa overlap, and to many others e.g. Escherichia coli SW:EFTU_ECOLI (P02990) (393 aa), Fasta scores: E(): 0, 74.9% identity in 395 aa overlap. Also similar to ML1498, ML1556, ML0611 and ML1878 from M. leprae. Contains Pfam match to entry PF00009 GTP_EFTU, Elongation factor Tu family. Contains PS00301 GTP-binding elongation factors signature. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22557972256987-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1877c|tuf
VAKAKFERTKPHVNIGTIGHVDHGKTTLTAAITKVLHDKFPNLNESRAFDQIDNAPEERQRGITINISHVEYQTEKRHYAHVDAPGHADYIKNMITGAAQMDGAILVVAATDGPMPQTREHVLLARQVGVPYILVALNKSDAVDDEELLELVEMEVRELLAAQEFDEDAPVVRVSALKALEGDAKWVESVTQLMDAVDESIPAPVRETDKPFLMPVEDVFTITGRGTVVTGRVERGVVNVNEEVEIVGIRQTTTKTTVTGVEMFRKLLDQGQAGDNVGLLLRGIKREDVERGQVVIKPGTTTPHTEFEGQVYILSKDEGGRHTPFFNNYRPQFYFRTTDVTGVVTLPEGTEMVMPGDNTNISVTLIQPVAMDEGLRFAIREGGRTVGAGRVVKIIK
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