Gene ML1890c in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namerpoC
Gene length3951 bp
IdentifierML1890c
Location 2269277 bp
Protein summary information
Molecular mass146863.0 Da
Isoelectric point6.57
Protein length1317 amino acids
Structural information
PFAMPF00623, PF04983, PF04997, PF04998, PF05000
Orthologs
M. tuberculosis H37RvRv0668
M. lepromatosis Mx1-22AMLPM_1890
Cross-references
UniProtP30761
Gene OntologyDna-directed rna polymerase activity, Transcription, dna-dependent, Dna binding
Enzyme Classification2.7.7.6
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductDNA-DIRECTED RNA POLYMERASE (BETA' CHAIN) RPOC (TRANSCRIPTASE BETA' CHAIN) (RNA POLYMERASE BETA' SUBUNIT).
CommentsML1890c, len: 1316 aa. Probable rpoC, DNA-directed RNA polymerase, beta' chain (EC 2.7.7.6). Similar to M. tuberculosis DNA-directed RNA polymerase beta chain Rv0668 SW:RPOC_MYCTU (P47769) (1316 aa), Fasta scores: E(): 0, 95.6% identity in 1316 aa overlap, and to many others e.g. Escherichia coli SW:RPOC_ECOLI (P00577) (1407 aa), Fasta scores: E(): 0, 42.5% identity in 1461 aa overlap. Contains Pfam match to entry PF00623 RNA_pol_A, RNA polymerase alpha subunit. Contains Pfam match to entry PF01854 RNA_pol_A2, RNA polymerase A/beta'/A subunit.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22692772273227-
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1890c|rpoC
VLDVNFFDELRIGLATAEDIRQWSYGEVKKPETINYRTLKPEKDGLFCEKIFGPTRDWECYCGKYKRVRFKGIICERCGVEVTRAKVRRERMGHIELAAPVTHIWYFKGVPSRLGYLLDLAPKDLEKIIYFAAYVITTVDEEMRHNELSTLEAEMMVERKSVEDQRDADLEARAQKLEADLAALEAEGAKADARRKFRDGGEREMRQLRERAQRELDRLEDIWSTFTKLAPKQLIVDENLYRELVDRYGEYFTGAMGAESIQKLMQDFDIEAEAESLREVIRNGKGQKKLRALKRLKVVAAFQQSGNSPMGMVLDAVPVIPPELRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLIDLGAPDIIVNNEKRMLQESVDALFDNGRRGRPVTGPGNRPLKSLSDLLKGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGLPKLMALELFKPFVMKRLVDLNHAQNIKSAKRMVERQRPQVWDVLEEVIAEHPVLLNRAPTLHRLGIQAFEPMLVEGKAIQLHPLVCEAFNADFDGDQMAVHLPLSAEAQAEARILMLSSNNILSPASGRPLAMPRLDMVTGLYYLTTAVDGDTGAYRPAAEDRPESGVYSSPAEAIMAADRGVLSVRAKIKVQLTQVRPPADIEARWFGANGWRPGDPWIADTTLGRVMFNELLPLGYPFVNKQMHKKVQAAIINDLAERYPMIVVAQTVDKLKDAGFYWATRSGVTVSMADVLVPPRKKEILDHYEERADKVEKQFQRGALNHDERNEALVEIWKEATDEVGQALRDHYPVDNPIITIVDSGATGNFTQTRALAGMKGLVTNPKGEFIPRPVKSSFREGLTVLEYFINTHGARKGLADTALRTADSGYLTRRLVDVSQDVIVREHDCQTERGIVVELAVRVPDGSLIRELYIETSAYARTLGANAVDEAGNVIVARGEDLGDPEIDALLAAGITQVKVRSVLTCTTGTGVCATCYGRSMATGKLVDIGEAVGIVAAQSIGEPGTQLTMRTFHQGGVGEDITGGLPRVQELFEARVPRGKAPIADVTGRVRLEDGERFYKITIVPDDGGEEVVYDKLSKRQRLRVFKHADGSERVLSDGDYVEVGQQLMEGSADPHEVLRVQGPREVQIHLVREVQEVYRAQGVSIHDKHIEVIVRQMLRRVTIIDSGSTEFLPGSLIDRAEFESENRRVVAESGEPAAGRPVLMGITKASLATDSWLSAASFQETTRVLTDAAINCRSDKLNGLKENVIIGKLIPAGTGINRYRNIQVQPTEEARASAYTIPSYEDQYYSPDFGQATGAAVPLDDYGYSDYR
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