Gene ML1899 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namelipG
Gene length915 bp
IdentifierML1899
Location 2283641 bp
Protein summary information
Molecular mass33339.2 Da
Isoelectric point9.56
Protein length305 amino acids
Structural information
PFAMPF00561
Orthologs
M. tuberculosis H37RvRv0646c
M. lepromatosis Mx1-22AMLPM_1899
Cross-references
UniProtQ9CBK5
Gene OntologyHydrolase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPROBABLE LIPASE/ESTERASE LIPG
CommentsML1899, len: 304 aa. probable lipG, lipase/esterase (EC 3.1.-.-). Similar to M. tuberculosis putative hydrolase Rv0646c TR:P96935 (EMBL:Z92772) (301 aa), Fasta scores: E(): 0, 71.3% identity in 303 aa overlap, and to others e.g. Escherichia coli macrolide 2'-phosphotransferase II TR:P77026 (EMBL:D85892) (279 aa), Fasta scores: E(): 1.3e-15, 31.3% identity in 291 aa overlap, and Streptomyces peucetius 10-carbomethoxy-13-deoxycarminomycin esterase TR:Q54809 (EMBL:L40425) (298 aa), Fasta scores: E(): 1e-09, 28.6% identity in 301 aa overlap. Also similar to ML0862 from M. leprae. Contains Pfam match to entry PF00561 abhydrolase, alpha/beta hydrolase fold.
Functional categoryIntermediary metabolism and respiration
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22836412284555+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1899|lipG
VEVRSGYATSGDLKLYYEDMGNVDDPPVLLIMGLGAQLVLWRTAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPSQPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHLSIERAHIVGASMGGMIAQIFAARFPTRTRSLAVFFSSNNRPFLPPPAPRALLALLTGPPTGSRRDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDRSFYPLGVSRQFSAILGSGSLLHYNQRIIAPTVVIHGRADKLVRPSSGRAVARAITGARLVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS
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