Gene ML1912 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene nameML1912
Gene length717 bp
IdentifierML1912
Location 2295531 bp
Protein summary information
Molecular mass26163.5 Da
Isoelectric point5.04
Protein length239 amino acids
Structural information
PFAMPF00753
Orthologs
M. tuberculosis H37RvRv0634c
M. lepromatosis Mx1-22AMLPM_1912
Cross-references
UniProtQ9CBJ4
Gene OntologyHydrolase activity
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionUnknown
ProductPOSSIBLE GLYOXALASE II (HYDROXYACYLGLUTATHIONE HYDROLASE) (GLX II)
CommentsML1912, len: 238 aa. Possible glyoxylase II (EC 3.1.2.6). Similar to M. tuberculosis putative glyoxylase II Rv0634c, to hypothetical proteins belonging to the glyoxalase II family e.g. Escherichia coli SW:YCBL_ECOLI (P75849) (215 aa), Fasta scores: E(): 3.5e-12, 32.5% identity in 203 aa overlap. Also similar to ML0493, ML2303 and ML1391 from M. leprae. Contains Pfam match to entry PF00753 lactamase_B, Metallo-beta-lactamase superfamily.
Functional categoryVirulence, detoxification, adaptation
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS22955312296247+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1912|ML1912
VSDSDRLYFRQLLSGRDFAVDDVVATQMRNFAYLIGDRQTGDCVVVDPAYAAGDLVDALEADGMRLSGVLVTHHHPDHVGGVMMGFQLKGLTELLERVTVPVHVNTHEALWISRVTGIDIGHLTTHEHRDKLSVGDIEIELLHTPGHTPGSQCFLLDGLLVAGDTLFLEGCGRTDFPGGNSDEMYRSLQQLAQLPGNPTVFPGHWYSTAPSATLSMVKCSNYVYRAADLNQWRMLMDS
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