Gene ML1941 in Mycobacterium leprae TN
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virulence, detoxification, adaptation
information pathways
cell wall and cell processes
stable RNAs
insertion seqs and phages
PE/PPE
intermediary metabolism and respiration
unknown
regulatory proteins
conserved hypotheticals
lipid metabolism
pseudogenes
Gene summary information
Gene namexseB
Gene length264 bp
IdentifierML1941
Location 2327636 bp
Protein summary information
Molecular mass9795.01 Da
Isoelectric point4.31
Protein length88 amino acids
Structural information
PFAMPF02609
Orthologs
M. tuberculosis H37RvRv1107c
M. lepromatosis Mx1-22AMLPM_1941
Cross-references
UniProtQ9X784
Gene OntologyCytoplasm, Exodeoxyribonuclease vii activity, Exodeoxyribonuclease vii complex, Dna catabolic process
Enzyme Classification3.1.11.6
Precomputed results
BLASTReport
General annotation
TypeCDS
FunctionBIDIRECTIONALLY DEGRADES SINGLE-STRANDED DNA INTO LARGE ACID-INSOLUBLE OLIGONUCLEOTIDES, WHICH ARE THEN DEGRADED FURTHER INTO SMALL ACID-SOLUBLE OLIGONUCLEOTIDES [CATALYTIC ACTIVITY: EXONUCLEOLYTIC CLEAVAGE IN EITHER 5'- TO 3'- OR 3'- TO 5'-DIRECTION TO YIELD 5'-PHOSPHOMONONUCLEOTIDES.]
ProductPROBABLE EXODEOXYRIBONUCLEASE VII (SMALL SUBUNIT) XSEA (EXONUCLEASE VII SMALL SUBUNIT)
CommentsML1941, len: 87 aa. Probable xseB, exonuclease VII small subunit (EC 3.1.11.6). Similar to M. tuberculosis exonuclease VII small subunit xseB Rv1107c, and to many others e.g. Escherichia coli exodeoxyribonuclease large subunit SW:EX7S_ECOLI (P22938) (79 aa), Fasta scores: E(): 0.021, 41.8% identity in 55 aa overlap.
Functional categoryInformation pathways
Mutant
Check for mutants available at TARGET website
Coordinates
TypeStartEndOrientation
CDS23276362327899+
Genomic sequence
Feature type Upstream flanking region (bp) Downstream flanking region (bp) Update
Protein sequence
>Mycobacterium leprae TN|ML1941|xseB
MVPEDDTAAMRSTTPINTTPINQLGYEACRDELIEVVRLLEQGGLNLDMSLKLWERGEQLAKRCEEHLDGARQRVADVLSARQVEEA
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