Gene ML1952c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | THOUGHT TO CATALYZE THE PRINCIPAL CONVERSION OF SATURATED FATTY ACIDS TO UNSATURATED FATTY ACIDS. THOUGHT TO CONVERT STEAROYL-ACP TO OLEOYL-ACP BY INTRODUCTION OF A CIS DOUBLE BOND BETWEEN CARBONS DELTA-9 AND DELTA-10 OF THE ACYL CHAIN [CATALYTIC ACTIVITY: Stearoyl-[acyl-carrier protein] + AH2 + O2 = oleoyl-[acyl-carrier protein] + A + 2 H2O]. |
| Product | POSSIBLE ACYL-[ACYL-CARRIER PROTEIN] DESATURASE DESA2 (ACYL-[ACP] DESATURASE) (STEAROYL-ACP DESATURASE) |
| Comments | ML1952c, len: 275 aa. Possible desA2, acyl-[acyl-carrier protein] desaturase (stearoyl-ACP desaturase) (EC 1.14.99.6). Similar to M. tuberculosis acyl-[ACP] desaturase desA2 TR:O53442 (EMBL:AL021897) (275 aa), Fasta scores: E(): 0, 78.1% identity in 274 aa overlap, and to others e.g. Gossypium hirsutum (Upland cotton) acyl-[acyl-carrier protein] desaturase precursor SW:STAD_GOSHI (X95988) (397 aa), Fasta scores: E(): 5.6e-05, 23.9% identity in 293 aa overlap. Also similar to ML2185 from M. leprae. |
| Functional category | Lipid metabolism |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2339277 | 2340104 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1952c|desA2
MAQKPVPNALILQLEPVVKDNMARHFANEELWFAHDYVPFDRGENFAFLGGRDWDPSQATLAKAVTDACEILLILKDNLAGYHRELVEHFILEGWWGRWLGRWTAEEHLHAIALREYLVVTREVDPVANEQVRVEHVMKGYRVNSYTQIETLVYMAFLERSYAFFCGSLAAQIKEPALFGLINQIVKDEVRHEEFFANLVAHCLECNRDETVAAIAARAAGLDVLGADIDAYHDKVENISAAGIFGSVELRQVISDRITAWGLINEPQLAQFVTS
Bibliography
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