Gene ML1957c
in Mycobacterium leprae TN
General annotation
| Type | CDS |
| Function | DNA-DEPENDENT RNA POLYMERASE CATALYZES THE TRANSCRIPTION OF DNA INTO RNA USING THE FOUR RIBONUCLEOSIDE TRIPHOSPHATES AS SUBSTRATES. THE AMINO-TERMINAL PORTION IS INVOLVED IN THE ASSEMBLY OF CORE RNAP, WHEREAS THE C-TERMINAL IS INVOLVED IN INTERACTION WITH TRANSCRIPTIONAL REGULATORS [CATALYTIC ACTIVITY: N NUCLEOSIDE TRIPHOSPHATE = N PYROPHOSPHATE + RNA(N)]. |
| Product | PROBABLE DNA-DIRECTED RNA POLYMERASE (ALPHA CHAIN) RPOA (TRANSCRIPTASE ALPHA CHAIN) (RNA POLYMERASE ALPHA SUBUNIT) (DNA-DIRECTED RNA NUCLEOTIDYLTRANSFERASE) |
| Comments | ML1957c, len: 347 aa. Probable rpoA, DNA-directed RNA polymerase (alpha chain) (EC 2.7.7.6). Similar to M. tuberculosis [alpha] subunit of RNA polymerase rpoA Rv3457c SW:RPOA_MYCTU (O06324) (347 aa), Fasta scores: E(): 0, 95.7% identity in 347 aa overlap. Contains Pfam match to entry PF01000 RNA_pol_A_bac, Bacterial RNA polymerase, alpha chain. Contains PS00017 ATP/GTP-binding site motif A (P-loop). |
| Functional category | Information pathways |
| Mutant | Check for mutants available at TARGET website |
Coordinates
| Type | Start | End | Orientation |
|---|---|---|---|
| CDS | 2344713 | 2345756 | - |
Genomic sequence
Feature type
Upstream flanking region (bp)
Downstream flanking region (bp)
Update
Protein sequence
>Mycobacterium leprae TN|ML1957c|rpoA
MLISQRPTLSEDILTDNRSQFVIEPLEPGFGYTLGNSLRRTLLSSIPGAAVTSIRIDGVLHEFTTVPGVKEDVTEIILNLKGLVVSSEEDEPVTMYLRKQGPGEVTAGDIVPPAGVTLHNPGMRIATLNDKGKIEAELVVERGRGYVPAVQNRALGAEIGRIPVDSIYSPVLKVTYKVDATRVEQRTDFDKLILDVETKSSITPRDALASAGKTLVELFGLARELNVEAEGIEIGPSPAEADHIASFALPIDDLDLTVRSYNCLKREGVHTVGELVSRTESDLLDIRNFGQKSIDEVKVKLHQLGLSLKDSPDSFDPSEVAGYDVTTGTWSTDGAYDSQDYAETEQL
Bibliography
No article yet recorded
